Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Clara Amalie Gade Timmermann; Esben Budtz-Jørgensen; Maria Skaalum Petersen; Pál Weihe; Ulrike Steuerwald; Flemming Nielsen; Tina Kold Jensen; Philippe Grandjean

doi:10.1016/j.reprotox.2016.07.010

Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Clara Amalie Gade Timmermann^*, Esben Budtz-Jørgensen, Maria Skaalum Petersen, Pál Weihe, Ulrike Steuerwald, Flemming Nielsen, Tina Kold Jensen, Philippe Grandjean

^*Corresponding author for this work

Section of Biostatistics

17 Citations (Scopus)

Abstract

The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

Original language	English
Journal	Reproductive Toxicology
Volume	68
Pages (from-to)	164–170
Number of pages	7
ISSN	0890-6238
DOIs	https://doi.org/10.1016/j.reprotox.2016.07.010
Publication status	Published - 1 Mar 2017

Keywords

Breast milk
Breastfeeding
Endocrine disruption
Lactation
Maternal health
Perfluoroalkyl substances

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.reprotox.2016.07.010

http://europepmc.org/articles/pmc5233673?pdf=renderLicence: Other

Cite this

@article{6b3a76ef1bb24c96a291579a92cf60da,

title = "Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances",

abstract = "The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.",

keywords = "Breast milk, Breastfeeding, Endocrine disruption, Lactation, Maternal health, Perfluoroalkyl substances",

author = "Timmermann, {Clara Amalie Gade} and Esben Budtz-J{\o}rgensen and Petersen, {Maria Skaalum} and P{\'a}l Weihe and Ulrike Steuerwald and Flemming Nielsen and Jensen, {Tina Kold} and Philippe Grandjean",

year = "2017",

month = mar,

day = "1",

doi = "10.1016/j.reprotox.2016.07.010",

language = "English",

volume = "68",

pages = "164–170",

journal = "Reproductive Toxicology",

issn = "0890-6238",

publisher = "Elsevier",

}

TY - JOUR

T1 - Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

AU - Timmermann, Clara Amalie Gade

AU - Budtz-Jørgensen, Esben

AU - Petersen, Maria Skaalum

AU - Weihe, Pál

AU - Steuerwald, Ulrike

AU - Nielsen, Flemming

AU - Jensen, Tina Kold

AU - Grandjean, Philippe

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

AB - The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

KW - Breast milk

KW - Breastfeeding

KW - Endocrine disruption

KW - Lactation

KW - Maternal health

KW - Perfluoroalkyl substances

UR - http://www.scopus.com/inward/record.url?scp=84979573900&partnerID=8YFLogxK

U2 - 10.1016/j.reprotox.2016.07.010

DO - 10.1016/j.reprotox.2016.07.010

M3 - Journal article

C2 - 27421579

AN - SCOPUS:84979573900

SN - 0890-6238

VL - 68

SP - 164

EP - 170

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this