Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Clara Amalie Gade Timmermann; Esben Budtz-Jørgensen; Maria Skaalum Petersen; Pál Weihe; Ulrike Steuerwald; Flemming Nielsen; Tina Kold Jensen; Philippe Grandjean

doi:10.1016/j.reprotox.2016.07.010

Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Clara Amalie Gade Timmermann^*, Esben Budtz-Jørgensen, Maria Skaalum Petersen, Pál Weihe, Ulrike Steuerwald, Flemming Nielsen, Tina Kold Jensen, Philippe Grandjean

^*Corresponding author af dette arbejde

Biostatistisk afdeling

17 Citationer (Scopus)

Abstract

The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

Originalsprog	Engelsk
Tidsskrift	Reproductive Toxicology
Vol/bind	68
Sider (fra-til)	164–170
Antal sider	7
ISSN	0890-6238
DOI	https://doi.org/10.1016/j.reprotox.2016.07.010
Status	Udgivet - 1 mar. 2017

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10.1016/j.reprotox.2016.07.010

http://europepmc.org/articles/pmc5233673?pdf=renderLicens: Andet

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abstract = "The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.",

keywords = "Breast milk, Breastfeeding, Endocrine disruption, Lactation, Maternal health, Perfluoroalkyl substances",

author = "Timmermann, {Clara Amalie Gade} and Esben Budtz-J{\o}rgensen and Petersen, {Maria Skaalum} and P{\'a}l Weihe and Ulrike Steuerwald and Flemming Nielsen and Jensen, {Tina Kold} and Philippe Grandjean",

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T1 - Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

AU - Timmermann, Clara Amalie Gade

AU - Budtz-Jørgensen, Esben

AU - Petersen, Maria Skaalum

AU - Weihe, Pál

AU - Steuerwald, Ulrike

AU - Nielsen, Flemming

AU - Jensen, Tina Kold

AU - Grandjean, Philippe

PY - 2017/3/1

Y1 - 2017/3/1

N2 - The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

AB - The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.

KW - Breast milk

KW - Breastfeeding

KW - Endocrine disruption

KW - Lactation

KW - Maternal health

KW - Perfluoroalkyl substances

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U2 - 10.1016/j.reprotox.2016.07.010

DO - 10.1016/j.reprotox.2016.07.010

M3 - Journal article

C2 - 27421579

AN - SCOPUS:84979573900

SN - 0890-6238

VL - 68

SP - 164

EP - 170

JO - Reproductive Toxicology

JF - Reproductive Toxicology

ER -

Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances

Abstract

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