Short-term effect of oral amoxicillin treatment on the gut microbial community composition in farm mink (Neovison vison)

TY - JOUR

T1 - Short-term effect of oral amoxicillin treatment on the gut microbial community composition in farm mink (Neovison vison)

AU - Marker, Laura Meier

AU - Hammer, Anne Sofie Vedsted

AU - Andresen, Lars

AU - Isaack, Pernille

AU - Clausen, Tove N.

AU - Byskov, Kevin

AU - Honore, Oliver Lykke

AU - Jensen, Søren Krogh

AU - Bahl, Martin Iain

PY - 2017/7/1

Y1 - 2017/7/1

N2 - It is well documented that antibiotics have pronounced modulatory effects on the intestinal bacterial community of both humans and animals, with potential health consequences. The gut microbiota of mink has however attracted little attention due to low bacterial load and fast gastrointestinal transit time, questioning its relevance. In this study, we hypothesise that oral amoxicillin treatment affects the gut microbiota in mink. This was investigated in a controlled trial including 24 animals of which 12 were treated with amoxicillin for 7 days. By applying 16S rRNA gene sequencing, we found that the faecal microbiota was markedly altered already after 2 days of treatment, with a surprising increase in diversity to resemble the feed. The diversity within the mucosa at termination was however reduced, which indicates this compartment as an important colonisation site in mink. No impact on blood biochemistry, lipid metabolism, serum amyloid A, vitamins A and E and histomorphology of the gut and liver was found; however, a slight decrease in fat digestibility was observed. We suggest that early-life use of amoxicillin in mink production may be counteractive as dysbiosis of the microbiota during infancy is increasingly being recognised as a risk factor for future health.

AB - It is well documented that antibiotics have pronounced modulatory effects on the intestinal bacterial community of both humans and animals, with potential health consequences. The gut microbiota of mink has however attracted little attention due to low bacterial load and fast gastrointestinal transit time, questioning its relevance. In this study, we hypothesise that oral amoxicillin treatment affects the gut microbiota in mink. This was investigated in a controlled trial including 24 animals of which 12 were treated with amoxicillin for 7 days. By applying 16S rRNA gene sequencing, we found that the faecal microbiota was markedly altered already after 2 days of treatment, with a surprising increase in diversity to resemble the feed. The diversity within the mucosa at termination was however reduced, which indicates this compartment as an important colonisation site in mink. No impact on blood biochemistry, lipid metabolism, serum amyloid A, vitamins A and E and histomorphology of the gut and liver was found; however, a slight decrease in fat digestibility was observed. We suggest that early-life use of amoxicillin in mink production may be counteractive as dysbiosis of the microbiota during infancy is increasingly being recognised as a risk factor for future health.

U2 - 10.1093/femsec/fix092

DO - 10.1093/femsec/fix092

M3 - Journal article

C2 - 28854681

SN - 0168-6496

VL - 93

JO - F E M S Microbiology Ecology

JF - F E M S Microbiology Ecology

IS - 7

M1 - fix092

ER -