Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

K V Haderslev; P B Jeppesen; B Hartmann; J Thulesen; H A Sorensen; J Graff; F Tofteng; S S Poulsen; J L Madsen; J J Holst; M Staun; P B Mortensen; Steen Seier Poulsen

Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

K V Haderslev, P B Jeppesen, B Hartmann, J Thulesen, H A Sorensen, J Graff, F Tofteng, S S Poulsen, J L Madsen, J J Holst, M Staun, P B Mortensen, Steen Seier Poulsen

72 Citations (Scopus)

Abstract

Glucagon-like peptide 2 (GLP-2) is a newly discovered intestinotrophic hormone. We have recently reported that a 5-week GLP-2 treatment improved the intestinal absorptive capacity of short-bowel patients with no colon. Additionally, GLP-2 treatment was associated with changes in body composition that included a significant increase in total body bone mass. This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients.

Original language	English
Journal	Scandinavian Journal of Gastroenterology
Volume	37
Issue number	4
Pages (from-to)	392-8
Number of pages	7
ISSN	0036-5521
Publication status	Published - 1 Apr 2002

Keywords

Absorptiometry, Photon
Adult
Alkaline Phosphatase
Amino Acids
Bone Density
Bone Diseases, Metabolic
Bone Remodeling
Calcium
Female
Gastrointestinal Hormones
Glucagon
Glucagon-Like Peptide 2
Glucagon-Like Peptides
Hormones
Humans
Intestinal Absorption
Male
Middle Aged
Osteocalcin
Osteoporosis
Parathyroid Hormone
Peptides
Pilot Projects
Short Bowel Syndrome
Vitamin D

Cite this

Haderslev, K. V., Jeppesen, P. B., Hartmann, B., Thulesen, J., Sorensen, H. A., Graff, J., Tofteng, F., Poulsen, S. S., Madsen, J. L., Holst, J. J., Staun, M., Mortensen, P. B., & Poulsen, S. S. (2002). Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon. Scandinavian Journal of Gastroenterology, 37(4), 392-8.

Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon. / Haderslev, K V; Jeppesen, P B ; Hartmann, B et al.

In: Scandinavian Journal of Gastroenterology, Vol. 37, No. 4, 01.04.2002, p. 392-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Haderslev, KV, Jeppesen, PB , Hartmann, B, Thulesen, J, Sorensen, HA, Graff, J, Tofteng, F, Poulsen, SS, Madsen, JL, Holst, JJ , Staun, M, Mortensen, PB & Poulsen, SS 2002, 'Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon', Scandinavian Journal of Gastroenterology, vol. 37, no. 4, pp. 392-8.

@article{42568f2c3bd4434c829ea9952cb61c72,

title = "Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon",

abstract = "Glucagon-like peptide 2 (GLP-2) is a newly discovered intestinotrophic hormone. We have recently reported that a 5-week GLP-2 treatment improved the intestinal absorptive capacity of short-bowel patients with no colon. Additionally, GLP-2 treatment was associated with changes in body composition that included a significant increase in total body bone mass. This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients.",

keywords = "Absorptiometry, Photon, Adult, Alkaline Phosphatase, Amino Acids, Bone Density, Bone Diseases, Metabolic, Bone Remodeling, Calcium, Female, Gastrointestinal Hormones, Glucagon, Glucagon-Like Peptide 2, Glucagon-Like Peptides, Hormones, Humans, Intestinal Absorption, Male, Middle Aged, Osteocalcin, Osteoporosis, Parathyroid Hormone, Peptides, Pilot Projects, Short Bowel Syndrome, Vitamin D",

author = "Haderslev, {K V} and Jeppesen, {P B} and B Hartmann and J Thulesen and Sorensen, {H A} and J Graff and F Tofteng and Poulsen, {S S} and Madsen, {J L} and Holst, {J J} and M Staun and Mortensen, {P B} and Poulsen, {Steen Seier}",

year = "2002",

month = apr,

day = "1",

language = "English",

volume = "37",

pages = "392--8",

journal = "Scandinavian Journal of Gastroenterology",

issn = "0036-5521",

publisher = "Taylor & Francis",

number = "4",

}

TY - JOUR

T1 - Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

AU - Haderslev, K V

AU - Jeppesen, P B

AU - Hartmann, B

AU - Thulesen, J

AU - Sorensen, H A

AU - Graff, J

AU - Tofteng, F

AU - Poulsen, S S

AU - Madsen, J L

AU - Holst, J J

AU - Staun, M

AU - Mortensen, P B

AU - Poulsen, Steen Seier

PY - 2002/4/1

Y1 - 2002/4/1

N2 - Glucagon-like peptide 2 (GLP-2) is a newly discovered intestinotrophic hormone. We have recently reported that a 5-week GLP-2 treatment improved the intestinal absorptive capacity of short-bowel patients with no colon. Additionally, GLP-2 treatment was associated with changes in body composition that included a significant increase in total body bone mass. This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients.

AB - Glucagon-like peptide 2 (GLP-2) is a newly discovered intestinotrophic hormone. We have recently reported that a 5-week GLP-2 treatment improved the intestinal absorptive capacity of short-bowel patients with no colon. Additionally, GLP-2 treatment was associated with changes in body composition that included a significant increase in total body bone mass. This article describes the effect of GLP-2 on spinal and hip bone mineral density (BMD) and biochemical markers of bone turnover in these patients.

KW - Absorptiometry, Photon

KW - Adult

KW - Alkaline Phosphatase

KW - Amino Acids

KW - Bone Density

KW - Bone Diseases, Metabolic

KW - Bone Remodeling

KW - Calcium

KW - Female

KW - Gastrointestinal Hormones

KW - Glucagon

KW - Glucagon-Like Peptide 2

KW - Glucagon-Like Peptides

KW - Hormones

KW - Humans

KW - Intestinal Absorption

KW - Male

KW - Middle Aged

KW - Osteocalcin

KW - Osteoporosis

KW - Parathyroid Hormone

KW - Peptides

KW - Pilot Projects

KW - Short Bowel Syndrome

KW - Vitamin D

M3 - Journal article

C2 - 11989828

SN - 0036-5521

VL - 37

SP - 392

EP - 398

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 4

ER -

Short-term administration of glucagon-like peptide-2. Effects on bone mineral density and markers of bone turnover in short-bowel patients with no colon

Abstract

Keywords

Fingerprint

Cite this