Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries: Individual Participant Data Meta-Analysis and Population Attributable Fraction

Naoko Kozuki; Joanne Katz; Anne Cc Lee; Joshua P Vogel; Mariangela F Silveira; Ayesha Sania; Gretchen A Stevens; Simon Cousens; Laura E Caulfield; Parul Christian; Lieven Huybregts; Dominique Roberfroid; Christentze Schmiegelow; Linda S Adair; Fernando C Barros; Melanie Cowan; Wafaie Fawzi; Patrick Kolsteren; Mario Merialdi; Aroonsri Mongkolchati; Naomi Saville; Cesar G Victora; Zulfiqar A Bhutta; Hannah Blencowe; Majid Ezzati; Joy E Lawn; Robert E Black; Child Health Epidemiology Reference Group Small-for-Gestational-Age/Preterm Birth Working Group

doi:10.3945/jn.115.216374

Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries: Individual Participant Data Meta-Analysis and Population Attributable Fraction

Naoko Kozuki, Joanne Katz, Anne Cc Lee, Joshua P Vogel, Mariangela F Silveira, Ayesha Sania, Gretchen A Stevens, Simon Cousens, Laura E Caulfield, Parul Christian, Lieven Huybregts, Dominique Roberfroid, Christentze Schmiegelow, Linda S Adair, Fernando C Barros, Melanie Cowan, Wafaie Fawzi, Patrick Kolsteren, Mario Merialdi, Aroonsri MongkolchatiNaomi Saville, Cesar G Victora, Zulfiqar A Bhutta, Hannah Blencowe, Majid Ezzati, Joy E Lawn, Robert E Black, Child Health Epidemiology Reference Group Small-for-Gestational-Age/Preterm Birth Working Group

75 Citations (Scopus)

Abstract

Background: Small-for-gestational-age (SGA) and preterm births are associated with adverse health consequences, including neonatal and infant mortality, childhood undernutrition, and adulthood chronic disease. Objectives: The specific aims of this study were to estimate the association between short maternal stature and outcomes of SGA alone, preterm birth alone, or both, and to calculate the population attributable fraction of SGA and preterm birth associated with short maternal stature. Methods: We conducted an individual participant data meta-analysis with the use of data sets from 12 population-based cohort studies and the WHO Global Survey on Maternal and Perinatal Health (13 of 24 available data sets used) from lowand middle-income countries (LMIC). We included those with weight taken within 72 h of birth, gestational age, and maternal height data (n = 177,000). For each of these studies, we individually calculated RRs between height exposure categories of <145 cm, 145 to <150 cm, and 150 to <155 cm (reference: ≥155 cm) and outcomes of SGA, preterm birth, and their combination categories. SGA was defined with the use of both the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) birth weight standard and the 1991 US birth weight reference. The associations were then meta-analyzed. Results: All short stature categories were statistically significantly associated with term SGA, preterm appropriate-forgestational- age (AGA), and preterm SGA births (reference: term AGA). When using the INTERGROWTH-21st standard to define SGA, women <145 cm had the highest adjusted risk ratios (aRRs) (term SGA-aRR: 2.03; 95% CI: 1.76, 2.35; preterm AGA-aRR: 1.45; 95% CI: 1.26, 1.66; preterm SGA-aRR: 2.13; 95% CI: 1.42, 3.21). Similar associations were seen for SGA defined by the US reference. Annually, 5.5 million term SGA (18.6% of the global total), 550,800 preterm AGA (5.0% of the global total), and 458,000 preterm SGA (16.5% of the global total) births may be associated with maternal short stature. Conclusions: Approximately 6.5 million SGA and/or preterm births in LMIC may be associated with short maternal stature annually. A reduction in this burden requires primary prevention of SGA, improvement in postnatal growth through early childhood, and possibly further intervention in late childhood and adolescence. It is vital for researchers to broaden the evidence base for addressing chronic malnutrition through multiple life stages, and for program implementers to explore effective, sustainable ways of reaching the most vulnerable populations.

Original language	English
Journal	Journal of Nutrition
Volume	145
Issue number	11
Pages (from-to)	2542-50
Number of pages	9
ISSN	0022-3166
DOIs	https://doi.org/10.3945/jn.115.216374
Publication status	Published - Nov 2015

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Kozuki, N., Katz, J., Lee, A. C., Vogel, J. P., Silveira, M. F., Sania, A., Stevens, G. A., Cousens, S., Caulfield, L. E., Christian, P., Huybregts, L., Roberfroid, D., Schmiegelow, C., Adair, L. S., Barros, F. C., Cowan, M., Fawzi, W., Kolsteren, P., Merialdi, M., ... Child Health Epidemiology Reference Group Small-for-Gestational-Age/Preterm Birth Working Group (2015). Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries: Individual Participant Data Meta-Analysis and Population Attributable Fraction. Journal of Nutrition, 145(11), 2542-50. https://doi.org/10.3945/jn.115.216374

Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries : Individual Participant Data Meta-Analysis and Population Attributable Fraction. / Kozuki, Naoko; Katz, Joanne; Lee, Anne Cc et al.

In: Journal of Nutrition, Vol. 145, No. 11, 11.2015, p. 2542-50.

Research output: Contribution to journal › Journal article › Research › peer-review

Kozuki, N, Katz, J, Lee, AC, Vogel, JP, Silveira, MF, Sania, A, Stevens, GA, Cousens, S, Caulfield, LE, Christian, P, Huybregts, L, Roberfroid, D, Schmiegelow, C, Adair, LS, Barros, FC, Cowan, M, Fawzi, W, Kolsteren, P, Merialdi, M, Mongkolchati, A, Saville, N, Victora, CG, Bhutta, ZA, Blencowe, H, Ezzati, M, Lawn, JE, Black, RE & Child Health Epidemiology Reference Group Small-for-Gestational-Age/Preterm Birth Working Group 2015, 'Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries: Individual Participant Data Meta-Analysis and Population Attributable Fraction', Journal of Nutrition, vol. 145, no. 11, pp. 2542-50. https://doi.org/10.3945/jn.115.216374

@article{d6303e44926940188383027423939c21,

title = "Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries: Individual Participant Data Meta-Analysis and Population Attributable Fraction",

abstract = "Background: Small-for-gestational-age (SGA) and preterm births are associated with adverse health consequences, including neonatal and infant mortality, childhood undernutrition, and adulthood chronic disease. Objectives: The specific aims of this study were to estimate the association between short maternal stature and outcomes of SGA alone, preterm birth alone, or both, and to calculate the population attributable fraction of SGA and preterm birth associated with short maternal stature. Methods: We conducted an individual participant data meta-analysis with the use of data sets from 12 population-based cohort studies and the WHO Global Survey on Maternal and Perinatal Health (13 of 24 available data sets used) from lowand middle-income countries (LMIC). We included those with weight taken within 72 h of birth, gestational age, and maternal height data (n = 177,000). For each of these studies, we individually calculated RRs between height exposure categories of <145 cm, 145 to <150 cm, and 150 to <155 cm (reference: ≥155 cm) and outcomes of SGA, preterm birth, and their combination categories. SGA was defined with the use of both the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) birth weight standard and the 1991 US birth weight reference. The associations were then meta-analyzed. Results: All short stature categories were statistically significantly associated with term SGA, preterm appropriate-forgestational- age (AGA), and preterm SGA births (reference: term AGA). When using the INTERGROWTH-21st standard to define SGA, women <145 cm had the highest adjusted risk ratios (aRRs) (term SGA-aRR: 2.03; 95% CI: 1.76, 2.35; preterm AGA-aRR: 1.45; 95% CI: 1.26, 1.66; preterm SGA-aRR: 2.13; 95% CI: 1.42, 3.21). Similar associations were seen for SGA defined by the US reference. Annually, 5.5 million term SGA (18.6% of the global total), 550,800 preterm AGA (5.0% of the global total), and 458,000 preterm SGA (16.5% of the global total) births may be associated with maternal short stature. Conclusions: Approximately 6.5 million SGA and/or preterm births in LMIC may be associated with short maternal stature annually. A reduction in this burden requires primary prevention of SGA, improvement in postnatal growth through early childhood, and possibly further intervention in late childhood and adolescence. It is vital for researchers to broaden the evidence base for addressing chronic malnutrition through multiple life stages, and for program implementers to explore effective, sustainable ways of reaching the most vulnerable populations.",

author = "Naoko Kozuki and Joanne Katz and Lee, {Anne Cc} and Vogel, {Joshua P} and Silveira, {Mariangela F} and Ayesha Sania and Stevens, {Gretchen A} and Simon Cousens and Caulfield, {Laura E} and Parul Christian and Lieven Huybregts and Dominique Roberfroid and Christentze Schmiegelow and Adair, {Linda S} and Barros, {Fernando C} and Melanie Cowan and Wafaie Fawzi and Patrick Kolsteren and Mario Merialdi and Aroonsri Mongkolchati and Naomi Saville and Victora, {Cesar G} and Bhutta, {Zulfiqar A} and Hannah Blencowe and Majid Ezzati and Lawn, {Joy E} and Black, {Robert E} and {Child Health Epidemiology Reference Group Small-for-Gestational-Age/Preterm Birth Working Group}",

note = "{\textcopyright} 2015 American Society for Nutrition.",

year = "2015",

month = nov,

doi = "10.3945/jn.115.216374",

language = "English",

volume = "145",

pages = "2542--50",

journal = "Journal of Nutrition",

issn = "0022-3166",

publisher = "American Society for Nutrition",

number = "11",

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TY - JOUR

T1 - Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries

T2 - Individual Participant Data Meta-Analysis and Population Attributable Fraction

AU - Kozuki, Naoko

AU - Katz, Joanne

AU - Lee, Anne Cc

AU - Vogel, Joshua P

AU - Silveira, Mariangela F

AU - Sania, Ayesha

AU - Stevens, Gretchen A

AU - Cousens, Simon

AU - Caulfield, Laura E

AU - Christian, Parul

AU - Huybregts, Lieven

AU - Roberfroid, Dominique

AU - Schmiegelow, Christentze

AU - Adair, Linda S

AU - Barros, Fernando C

AU - Cowan, Melanie

AU - Fawzi, Wafaie

AU - Kolsteren, Patrick

AU - Merialdi, Mario

AU - Mongkolchati, Aroonsri

AU - Saville, Naomi

AU - Victora, Cesar G

AU - Bhutta, Zulfiqar A

AU - Blencowe, Hannah

AU - Ezzati, Majid

AU - Lawn, Joy E

AU - Black, Robert E

AU - Child Health Epidemiology Reference Group Small-for-Gestational-Age/Preterm Birth Working Group

PY - 2015/11

Y1 - 2015/11

N2 - Background: Small-for-gestational-age (SGA) and preterm births are associated with adverse health consequences, including neonatal and infant mortality, childhood undernutrition, and adulthood chronic disease. Objectives: The specific aims of this study were to estimate the association between short maternal stature and outcomes of SGA alone, preterm birth alone, or both, and to calculate the population attributable fraction of SGA and preterm birth associated with short maternal stature. Methods: We conducted an individual participant data meta-analysis with the use of data sets from 12 population-based cohort studies and the WHO Global Survey on Maternal and Perinatal Health (13 of 24 available data sets used) from lowand middle-income countries (LMIC). We included those with weight taken within 72 h of birth, gestational age, and maternal height data (n = 177,000). For each of these studies, we individually calculated RRs between height exposure categories of <145 cm, 145 to <150 cm, and 150 to <155 cm (reference: ≥155 cm) and outcomes of SGA, preterm birth, and their combination categories. SGA was defined with the use of both the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) birth weight standard and the 1991 US birth weight reference. The associations were then meta-analyzed. Results: All short stature categories were statistically significantly associated with term SGA, preterm appropriate-forgestational- age (AGA), and preterm SGA births (reference: term AGA). When using the INTERGROWTH-21st standard to define SGA, women <145 cm had the highest adjusted risk ratios (aRRs) (term SGA-aRR: 2.03; 95% CI: 1.76, 2.35; preterm AGA-aRR: 1.45; 95% CI: 1.26, 1.66; preterm SGA-aRR: 2.13; 95% CI: 1.42, 3.21). Similar associations were seen for SGA defined by the US reference. Annually, 5.5 million term SGA (18.6% of the global total), 550,800 preterm AGA (5.0% of the global total), and 458,000 preterm SGA (16.5% of the global total) births may be associated with maternal short stature. Conclusions: Approximately 6.5 million SGA and/or preterm births in LMIC may be associated with short maternal stature annually. A reduction in this burden requires primary prevention of SGA, improvement in postnatal growth through early childhood, and possibly further intervention in late childhood and adolescence. It is vital for researchers to broaden the evidence base for addressing chronic malnutrition through multiple life stages, and for program implementers to explore effective, sustainable ways of reaching the most vulnerable populations.

AB - Background: Small-for-gestational-age (SGA) and preterm births are associated with adverse health consequences, including neonatal and infant mortality, childhood undernutrition, and adulthood chronic disease. Objectives: The specific aims of this study were to estimate the association between short maternal stature and outcomes of SGA alone, preterm birth alone, or both, and to calculate the population attributable fraction of SGA and preterm birth associated with short maternal stature. Methods: We conducted an individual participant data meta-analysis with the use of data sets from 12 population-based cohort studies and the WHO Global Survey on Maternal and Perinatal Health (13 of 24 available data sets used) from lowand middle-income countries (LMIC). We included those with weight taken within 72 h of birth, gestational age, and maternal height data (n = 177,000). For each of these studies, we individually calculated RRs between height exposure categories of <145 cm, 145 to <150 cm, and 150 to <155 cm (reference: ≥155 cm) and outcomes of SGA, preterm birth, and their combination categories. SGA was defined with the use of both the International Fetal and Newborn Growth Consortium for the 21st Century (INTERGROWTH-21st) birth weight standard and the 1991 US birth weight reference. The associations were then meta-analyzed. Results: All short stature categories were statistically significantly associated with term SGA, preterm appropriate-forgestational- age (AGA), and preterm SGA births (reference: term AGA). When using the INTERGROWTH-21st standard to define SGA, women <145 cm had the highest adjusted risk ratios (aRRs) (term SGA-aRR: 2.03; 95% CI: 1.76, 2.35; preterm AGA-aRR: 1.45; 95% CI: 1.26, 1.66; preterm SGA-aRR: 2.13; 95% CI: 1.42, 3.21). Similar associations were seen for SGA defined by the US reference. Annually, 5.5 million term SGA (18.6% of the global total), 550,800 preterm AGA (5.0% of the global total), and 458,000 preterm SGA (16.5% of the global total) births may be associated with maternal short stature. Conclusions: Approximately 6.5 million SGA and/or preterm births in LMIC may be associated with short maternal stature annually. A reduction in this burden requires primary prevention of SGA, improvement in postnatal growth through early childhood, and possibly further intervention in late childhood and adolescence. It is vital for researchers to broaden the evidence base for addressing chronic malnutrition through multiple life stages, and for program implementers to explore effective, sustainable ways of reaching the most vulnerable populations.

U2 - 10.3945/jn.115.216374

DO - 10.3945/jn.115.216374

M3 - Journal article

C2 - 26423738

SN - 0022-3166

VL - 145

SP - 2542

EP - 2550

JO - Journal of Nutrition

JF - Journal of Nutrition

IS - 11

ER -

Short Maternal Stature Increases Risk of Small-for-Gestational-Age and Preterm Births in Low- and Middle-Income Countries: Individual Participant Data Meta-Analysis and Population Attributable Fraction

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