Abstract
To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.
| Original language | English |
|---|---|
| Journal | APMIS - Journal of Pathology, Microbiology and Immunology |
| Volume | 124 |
| Issue number | 9 |
| Pages (from-to) | 770-775 |
| Number of pages | 6 |
| ISSN | 0903-4641 |
| DOIs | |
| Publication status | Published - 1 Sept 2016 |
Keywords
- Adolescent
- Adult
- Biomarkers
- Chitinase-3-Like Protein 1
- Cohort Studies
- Diabetes, Gestational
- Female
- Glucose Tolerance Test
- Humans
- Middle Aged
- Pregnancy
- Serum
- Young Adult
- Journal Article
- Observational Study
