Abstract
To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | APMIS - Journal of Pathology, Microbiology and Immunology |
| Vol/bind | 124 |
| Udgave nummer | 9 |
| Sider (fra-til) | 770-775 |
| Antal sider | 6 |
| ISSN | 0903-4641 |
| DOI | |
| Status | Udgivet - 1 sep. 2016 |
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