Serum YKL-40 and gestational diabetes - an observational cohort study

Dorte Gybel-Brask; Julia S Johansen; Ib J Christiansen; Lillian Skibsted; Estrid V S Høgdall

doi:10.1111/apm.12573

Serum YKL-40 and gestational diabetes - an observational cohort study

Dorte Gybel-Brask, Julia S Johansen, Ib J Christiansen, Lillian Skibsted, Estrid V S Høgdall

Institut for Klinisk Medicin

4 Citationer (Scopus)

Abstract

To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.

Originalsprog	Engelsk
Tidsskrift	APMIS - Journal of Pathology, Microbiology and Immunology
Vol/bind	124
Udgave nummer	9
Sider (fra-til)	770-775
Antal sider	6
ISSN	0903-4641
DOI	https://doi.org/10.1111/apm.12573
Status	Udgivet - 1 sep. 2016

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title = "Serum YKL-40 and gestational diabetes - an observational cohort study",

abstract = "To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.",

keywords = "Adolescent, Adult, Biomarkers, Chitinase-3-Like Protein 1, Cohort Studies, Diabetes, Gestational, Female, Glucose Tolerance Test, Humans, Middle Aged, Pregnancy, Serum, Young Adult, Journal Article, Observational Study",

author = "Dorte Gybel-Brask and Johansen, {Julia S} and Christiansen, {Ib J} and Lillian Skibsted and H{\o}gdall, {Estrid V S}",

note = "{\textcopyright} 2016 APMIS. Published by John Wiley & Sons Ltd.",

year = "2016",

month = sep,

day = "1",

doi = "10.1111/apm.12573",

language = "English",

volume = "124",

pages = "770--775",

journal = "APMIS. Supplementum",

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TY - JOUR

T1 - Serum YKL-40 and gestational diabetes - an observational cohort study

AU - Gybel-Brask, Dorte

AU - Johansen, Julia S

AU - Christiansen, Ib J

AU - Skibsted, Lillian

AU - Høgdall, Estrid V S

PY - 2016/9/1

Y1 - 2016/9/1

N2 - To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.

AB - To examine serum YKL-40 in women developing gestational diabetes mellitus (GDM). In the present large observational cohort study of 1179 pregnant women, we determined serum YKL-40 four times during pregnancy (at gestational age 12, 20, 25, and 32 weeks). Pregnancy outcome was obtained from medical records. Sixty-eight women (5.8%) developed GDM. Serum YKL-40 increased from gestational age (GA) 12 weeks and the following weeks in the women who developed GDM and was independent of BMI, parity, and maternal age (OR = 2.69, 95% CI: 1.45-5.00, p = 0.002). No association was found between serum YKL-40 and the oral glucose tolerance test results. In conclusion, YKL-40 significantly increased in pregnant women with GDM compared with women without GDM, probably reflecting the low-grade inflammation of GDM. However, we did not find an association between serum concentrations of YKL-40 in early pregnancy and the development of GDM and thus we conclude that YKL-40 alone is not usable as a biomarker for early prediction of GDM.

KW - Adolescent

KW - Adult

KW - Biomarkers

KW - Chitinase-3-Like Protein 1

KW - Cohort Studies

KW - Diabetes, Gestational

KW - Female

KW - Glucose Tolerance Test

KW - Humans

KW - Middle Aged

KW - Pregnancy

KW - Serum

KW - Young Adult

KW - Journal Article

KW - Observational Study

U2 - 10.1111/apm.12573

DO - 10.1111/apm.12573

M3 - Journal article

C2 - 27457220

SN - 0903-465X

VL - 124

SP - 770

EP - 775

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 9

ER -

Serum YKL-40 and gestational diabetes - an observational cohort study

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