Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria

P H Jakobsen; E Hundt; Morten Bagge Hansen; B Knapp

Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria

P H Jakobsen, E Hundt, Morten Bagge Hansen, B Knapp

Centre for Medical Parasitology

2 Citations (Scopus)

Abstract

A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine-stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin-binding protein, the histidine-rich protein II, the S-antigen, the heat shock protein 70, the ring-infected erythrocyte surface antigen, and the apical membrane antigen-1 were also shown serologically to be present in the mixture of exoantigens.

Original language	English
Journal	Acta Pathologica Microbiologica et Immunologica Scandinavica
Volume	102
Issue number	1
Pages (from-to)	53-8
Number of pages	5
ISSN	0903-4641
Publication status	Published - 1994

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Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria. / Jakobsen, P H; Hundt, E; Hansen, Morten Bagge et al.

In: Acta Pathologica Microbiologica et Immunologica Scandinavica, Vol. 102, No. 1, 1994, p. 53-8.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria",

abstract = "A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine-stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin-binding protein, the histidine-rich protein II, the S-antigen, the heat shock protein 70, the ring-infected erythrocyte surface antigen, and the apical membrane antigen-1 were also shown serologically to be present in the mixture of exoantigens.",

author = "Jakobsen, {P H} and E Hundt and Hansen, {Morten Bagge} and B Knapp",

note = "Keywords: Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Humans; Immune Sera; Immunoblotting; Immunoelectrophoresis, Two-Dimensional; Malaria Vaccines; Malaria, Falciparum; Molecular Sequence Data; Proteins; Protozoan Proteins; Rabbits",

year = "1994",

language = "English",

volume = "102",

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journal = "APMIS. Supplementum",

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T1 - Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria

AU - Jakobsen, P H

AU - Hundt, E

AU - Hansen, Morten Bagge

AU - Knapp, B

N1 - Keywords: Amino Acid Sequence; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antigens, Surface; Electrophoresis, Polyacrylamide Gel; Heat-Shock Proteins; Humans; Immune Sera; Immunoblotting; Immunoelectrophoresis, Two-Dimensional; Malaria Vaccines; Malaria, Falciparum; Molecular Sequence Data; Proteins; Protozoan Proteins; Rabbits

PY - 1994

Y1 - 1994

N2 - A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine-stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin-binding protein, the histidine-rich protein II, the S-antigen, the heat shock protein 70, the ring-infected erythrocyte surface antigen, and the apical membrane antigen-1 were also shown serologically to be present in the mixture of exoantigens.

AB - A mixture of Plasmodium falciparum exoantigens inducing lymphocyte activation and cytokine production was shown to contain the malaria vaccine candidate, the serine-stretch protein. This protein was shown serologically to correspond to Ag2, an exoantigen recognized by antibodies linked with protection against malaria. The glycophorin-binding protein, the histidine-rich protein II, the S-antigen, the heat shock protein 70, the ring-infected erythrocyte surface antigen, and the apical membrane antigen-1 were also shown serologically to be present in the mixture of exoantigens.

M3 - Journal article

C2 - 8167001

SN - 0903-465X

VL - 102

SP - 53

EP - 58

JO - APMIS. Supplementum

JF - APMIS. Supplementum

IS - 1

ER -

Serine-stretch protein (SERP) of Plasmodium falciparum corresponds to the exoantigen Ag2, a target of antibodies associated with protection against malaria

Abstract

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