Abstract
Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.
| Translated title of the contribution | Medicaments and oral healthcare. Systematic review of the -literature assessing the effect of drugs on the salivary glands |
|---|---|
| Original language | Dutch |
| Journal | Nederlands Tijdschrift voor Tandheelkunde |
| Volume | 125 |
| Issue number | 11 |
| Pages (from-to) | 593-601 |
| Number of pages | 9 |
| ISSN | 0028-2200 |
| DOIs | |
| Publication status | Published - Nov 2018 |