Serie: Medicamenten en mondzorg.Systematisch literatuuronderzoek naar effect van medicatie op de speekselklieren

TY - JOUR

T1 - Serie

T2 - Medicamenten en mondzorg.Systematisch literatuuronderzoek naar effect van medicatie op de speekselklieren

AU - Wolff, A

AU - Joshi, R K

AU - Ekström, J

AU - Aframian, D

AU - Pedersen, A M L

AU - Proctor, G

AU - Narayana, N

AU - Villa, A

AU - Sia, Y W

AU - Aliko, A

AU - McGowan, R

AU - Kerr, R

AU - Jensen, S B

AU - Vissink, A

AU - Dawes, C

PY - 2018/11

Y1 - 2018/11

N2 - Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.

AB - Evidence-based reviews of drugs causing medication-induced salivary gland dysfunction, such as xerostomia (sensation of oral dryness) and subjective sialorrhea are lacking. To compile a list of medicaments that influence salivary gland function, electronic databases were searched for relevant articles published up to June 2013. A total of 269 papers out of 3,867 records located satisfied the inclusion criteria (relevance, quality of methodology, strength of evidence). A total of 56 active substances with a higher level of evidence and 50 active substances with a moderate level of evidence of causing salivary gland dysfunction are described in this article. While xerostomia was a commonly reported outcome, the objective effect on salivary secretion was rarely measured. Xerostomia was, moreover, mostly reported as a negative side effect instead of the intended effect of that drug. A comprehensive list of medications having documented effects on salivary gland function or symptoms was compiled, which may assist practitioners in assessing patients who complain of dry mouth while taking medications.

U2 - 10.5177/ntvt.2018.11.18203

DO - 10.5177/ntvt.2018.11.18203

M3 - Tidsskriftartikel

C2 - 30457580

SN - 0028-2200

VL - 125

SP - 593

EP - 601

JO - Nederlands Tijdschrift voor Tandheelkunde

JF - Nederlands Tijdschrift voor Tandheelkunde

IS - 11

ER -