Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

Søren Jensen; Allan Randrup Thomsen

doi:10.1128/JVI.05738-11

Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

Søren Jensen, Allan Randrup Thomsen

Department of Immunology and Microbiology

303 Citations (Scopus)

Abstract

Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

Original language	English
Journal	Journal of Virology
Volume	86
Issue number	6
Pages (from-to)	2900-2910
Number of pages	11
ISSN	0022-538X
DOIs	https://doi.org/10.1128/JVI.05738-11
Publication status	Published - Mar 2012

Keywords

Animals
Humans
Immunity, Innate
RNA Virus Infections
RNA Viruses
Receptors, Immunologic

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10.1128/JVI.05738-11

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abstract = "Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.",

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KW - Humans

KW - Immunity, Innate

KW - RNA Virus Infections

KW - RNA Viruses

KW - Receptors, Immunologic

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Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

Abstract

Keywords

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