Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

TY - JOUR

T1 - Sensing of RNA viruses

T2 - a review of innate immune receptors involved in recognizing RNA virus invasion

AU - Jensen, Søren

AU - Thomsen, Allan Randrup

PY - 2012/3

Y1 - 2012/3

N2 - Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

AB - Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.

KW - Animals

KW - Humans

KW - Immunity, Innate

KW - RNA Virus Infections

KW - RNA Viruses

KW - Receptors, Immunologic

U2 - 10.1128/JVI.05738-11

DO - 10.1128/JVI.05738-11

M3 - Journal article

C2 - 22258243

SN - 0022-538X

VL - 86

SP - 2900

EP - 2910

JO - Journal of Virology

JF - Journal of Virology

IS - 6

ER -