Self-assembling drugs: A new therapeutic strategy

N. Hassan; Juan M. Ruso; Gonzalez Perez Alfredo

doi:10.1039/c0sm01529f

Self-assembling drugs: A new therapeutic strategy

N. Hassan, Juan M. Ruso, Gonzalez Perez Alfredo

11 Citations (Scopus)

Abstract

In the current work we proposed the new idea of "self-assembled drug" based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.

Original language	English
Journal	Soft Matter
Volume	7
Issue number	11
Pages (from-to)	5194-5199
Number of pages	5
ISSN	1744-683X
DOIs	https://doi.org/10.1039/c0sm01529f
Publication status	Published - 7 Jun 2011

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title = "Self-assembling drugs: A new therapeutic strategy",

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AU - Hassan, N.

AU - Ruso, Juan M.

AU - Alfredo, Gonzalez Perez

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N2 - In the current work we proposed the new idea of "self-assembled drug" based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.

AB - In the current work we proposed the new idea of "self-assembled drug" based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.

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DO - 10.1039/c0sm01529f

M3 - Journal article

SN - 1744-683X

VL - 7

SP - 5194

EP - 5199

JO - Soft Matter

JF - Soft Matter

IS - 11

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Self-assembling drugs: A new therapeutic strategy

Abstract

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