Self-assembling drugs: A new therapeutic strategy

N. Hassan; Juan M. Ruso; Gonzalez Perez Alfredo

doi:10.1039/c0sm01529f

Self-assembling drugs: A new therapeutic strategy

N. Hassan, Juan M. Ruso, Gonzalez Perez Alfredo

11 Citationer (Scopus)

Abstract

In the current work we proposed the new idea of "self-assembled drug" based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.

Originalsprog	Engelsk
Tidsskrift	Soft Matter
Vol/bind	7
Udgave nummer	11
Sider (fra-til)	5194-5199
Antal sider	5
ISSN	1744-683X
DOI	https://doi.org/10.1039/c0sm01529f
Status	Udgivet - 7 jun. 2011

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10.1039/c0sm01529f

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abstract = "In the current work we proposed the new idea of {"}self-assembled drug{"} based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.",

author = "N. Hassan and Ruso, {Juan M.} and Alfredo, {Gonzalez Perez}",

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T2 - A new therapeutic strategy

AU - Hassan, N.

AU - Ruso, Juan M.

AU - Alfredo, Gonzalez Perez

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AB - In the current work we proposed the new idea of "self-assembled drug" based on the combination of two or more drugs. As model system we used hexadecyldimethylammonium bromide: dicloxacilin at room temperature. The two drugs are well known for their therapeutic effect and together form worm-like micelles with the combined therapeutic effect of both individual compounds. The system was investigated using, density and sound velocity, dynamic light scattering and cryo- electron microscopy (cryo-TEM) and UV for a complete physicochemical and stability characterization.

U2 - 10.1039/c0sm01529f

DO - 10.1039/c0sm01529f

M3 - Journal article

SN - 1744-683X

VL - 7

SP - 5194

EP - 5199

JO - Soft Matter

JF - Soft Matter

IS - 11

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Self-assembling drugs: A new therapeutic strategy

Abstract

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