Selective copper catalysed aromatic N-arylation in water

Jens Engel-Andreasen; Bharat Shimpukade; Trond. Ulven

doi:10.1039/c2gc36589h

Selective copper catalysed aromatic N-arylation in water

Jens Engel-Andreasen, Bharat Shimpukade, Trond. Ulven

65 Citations (Scopus)

Abstract

4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

Original language	English
Journal	Green Chemistry
Volume	15
Issue number	2
Pages (from-to)	336-340
Number of pages	5
ISSN	1463-9262
DOIs	https://doi.org/10.1039/c2gc36589h
Publication status	Published - Feb 2013

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abstract = "4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.",

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AU - Engel-Andreasen, Jens

AU - Shimpukade, Bharat

AU - Ulven, Trond.

PY - 2013/2

Y1 - 2013/2

N2 - 4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

AB - 4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

U2 - 10.1039/c2gc36589h

DO - 10.1039/c2gc36589h

M3 - Journal article

SN - 1463-9262

VL - 15

SP - 336

EP - 340

JO - Green Chemistry

JF - Green Chemistry

IS - 2

ER -

Selective copper catalysed aromatic N-arylation in water

Abstract

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