Selective copper catalysed aromatic N-arylation in water

Jens Engel-Andreasen; Bharat Shimpukade; Trond. Ulven

doi:10.1039/c2gc36589h

Selective copper catalysed aromatic N-arylation in water

Jens Engel-Andreasen, Bharat Shimpukade, Trond. Ulven

65 Citationer (Scopus)

Abstract

4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

Originalsprog	Engelsk
Tidsskrift	Green Chemistry
Vol/bind	15
Udgave nummer	2
Sider (fra-til)	336-340
Antal sider	5
ISSN	1463-9262
DOI	https://doi.org/10.1039/c2gc36589h
Status	Udgivet - feb. 2013

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10.1039/c2gc36589h

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title = "Selective copper catalysed aromatic N-arylation in water",

abstract = "4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.",

author = "Jens Engel-Andreasen and Bharat Shimpukade and Trond. Ulven",

year = "2013",

month = feb,

doi = "10.1039/c2gc36589h",

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volume = "15",

pages = "336--340",

journal = "Green Chemistry",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Selective copper catalysed aromatic N-arylation in water

AU - Engel-Andreasen, Jens

AU - Shimpukade, Bharat

AU - Ulven, Trond.

PY - 2013/2

Y1 - 2013/2

N2 - 4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

AB - 4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

U2 - 10.1039/c2gc36589h

DO - 10.1039/c2gc36589h

M3 - Journal article

SN - 1463-9262

VL - 15

SP - 336

EP - 340

JO - Green Chemistry

JF - Green Chemistry

IS - 2

ER -

Selective copper catalysed aromatic N-arylation in water

Abstract

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