TY - JOUR
T1 - Second meal effect on appetite and fermentation of wholegrain rye foods
AU - Ibrügger, Sabine
AU - Vigsnæs, Louise Kristine
AU - Blennow, Andreas
AU - Skuflic, Dan
AU - Raben, Anne
AU - Lauritzen, Lotte
AU - Kristensen, Mette Bredal
N1 - CURIS 2014 NEXS 209
PY - 2014/9/1
Y1 - 2014/9/1
N2 - Background: Wholegrain rye has been associated with decreased hunger sensations. This may be partly mediated by colonic fermentation. Sustained consumption of fermentable components is known to change the gut microflora and may increase numbers of saccharolytic bacteria. Objective: To investigate the effect of wholegrain rye consumption on appetite and colonic fermentation after a subsequent meal. Methods: In a randomized, controlled, three-arm cross-over study, twelve healthy male subjects consumed three iso-caloric evening test meals. The test meals were based on white wheat bread (WBB), wholegrain rye kernel bread (RKB), or boiled rye kernels (RK). Breath hydrogen excretion and subjective appetite sensation were measured before and at 30min intervals for 3h after a standardized breakfast in the subsequent morning. After the 3han ad libitum lunch meal was served to assess energy intake. In an in vitro stud RKB and RK were subjected to digestion and 24h-fermentation in order to study SCFA production and growth of selected saccharolytic bacteria. Results: The test meals did not differ in their effect on parameters of subjective appetite sensation the following day. Ad libitum energy intake at lunch was, however, reduced by 11% (P<0.01) after RKB and 7% (P<0.05) after RK compared with after WWB evening meal. Breath hydrogen excretion was significantly increased following RKB and RK evening meals compared with WWB (P<0.01 and P<0.05, respectively). Overall, RKB and RK were readily fermented in vitro and exhibited similar fermentation profiles, although total SCFA production was higher for RK compared with RKB (P<0.001). In vitro fermentation of RKB and RK both increased the relative quantities of Bifidobacterium and decreased Bacteroides compared with inoculum (P<0.001). The C. coccoides group was reduced after RKB (P<0.001). Conclusion: Consumption of wholegrain rye products reduced subsequent ad libitum energy intake in young healthy men, possibly mediated by mechanisms related to colonic fermentation.
AB - Background: Wholegrain rye has been associated with decreased hunger sensations. This may be partly mediated by colonic fermentation. Sustained consumption of fermentable components is known to change the gut microflora and may increase numbers of saccharolytic bacteria. Objective: To investigate the effect of wholegrain rye consumption on appetite and colonic fermentation after a subsequent meal. Methods: In a randomized, controlled, three-arm cross-over study, twelve healthy male subjects consumed three iso-caloric evening test meals. The test meals were based on white wheat bread (WBB), wholegrain rye kernel bread (RKB), or boiled rye kernels (RK). Breath hydrogen excretion and subjective appetite sensation were measured before and at 30min intervals for 3h after a standardized breakfast in the subsequent morning. After the 3han ad libitum lunch meal was served to assess energy intake. In an in vitro stud RKB and RK were subjected to digestion and 24h-fermentation in order to study SCFA production and growth of selected saccharolytic bacteria. Results: The test meals did not differ in their effect on parameters of subjective appetite sensation the following day. Ad libitum energy intake at lunch was, however, reduced by 11% (P<0.01) after RKB and 7% (P<0.05) after RK compared with after WWB evening meal. Breath hydrogen excretion was significantly increased following RKB and RK evening meals compared with WWB (P<0.01 and P<0.05, respectively). Overall, RKB and RK were readily fermented in vitro and exhibited similar fermentation profiles, although total SCFA production was higher for RK compared with RKB (P<0.001). In vitro fermentation of RKB and RK both increased the relative quantities of Bifidobacterium and decreased Bacteroides compared with inoculum (P<0.001). The C. coccoides group was reduced after RKB (P<0.001). Conclusion: Consumption of wholegrain rye products reduced subsequent ad libitum energy intake in young healthy men, possibly mediated by mechanisms related to colonic fermentation.
U2 - 10.1016/j.appet.2014.05.026
DO - 10.1016/j.appet.2014.05.026
M3 - Journal article
C2 - 24874564
SN - 0195-6663
VL - 80
SP - 248
EP - 256
JO - Appetite
JF - Appetite
ER -