Scaffold Diversity from N-Acyliminium Ions

Peng Wu; Thomas E. Nielsen

doi:10.1021/acs.chemrev.6b00806

Scaffold Diversity from N-Acyliminium Ions

Peng Wu^*, Thomas E. Nielsen

^*Corresponding author for this work

87 Citations (Scopus)

Abstract

N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).

Original language	English
Journal	Chemical Reviews
Volume	117
Issue number	12
Pages (from-to)	7811-7856
Number of pages	46
ISSN	0009-2665
DOIs	https://doi.org/10.1021/acs.chemrev.6b00806
Publication status	Published - 2017

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10.1021/acs.chemrev.6b00806

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abstract = "N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).",

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AB - N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).

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Scaffold Diversity from N-Acyliminium Ions

Abstract

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