Scaffold Diversity from N-Acyliminium Ions

TY - JOUR

T1 - Scaffold Diversity from N-Acyliminium Ions

AU - Wu, Peng

AU - Nielsen, Thomas E.

PY - 2017

Y1 - 2017

N2 - N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).

AB - N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).

U2 - 10.1021/acs.chemrev.6b00806

DO - 10.1021/acs.chemrev.6b00806

M3 - Review

C2 - 28493667

AN - SCOPUS:85021630755

SN - 0009-2665

VL - 117

SP - 7811

EP - 7856

JO - Chemical Reviews

JF - Chemical Reviews

IS - 12

ER -