Role of vitamin C and E supplementation on IL-6 in response to training

Christina Yfanti; Christian P. Fischer; Søren Nielsen; Thorbjörn Åkerström; Anders R. Nielsen; Aristidis S. Veskoukis; Demetrios Kouretas; Jens Lykkesfeldt; Henriette Pilegaard; Bente Klarlund Pedersen

doi:10.1152/japplphysiol.01027.2010

Role of vitamin C and E supplementation on IL-6 in response to training

Christina Yfanti, Christian P. Fischer, Søren Nielsen, Thorbjörn Åkerström, Anders R. Nielsen, Aristidis S. Veskoukis, Demetrios Kouretas, Jens Lykkesfeldt, Henriette Pilegaard, Bente Klarlund Pedersen

45 Citations (Scopus)

Abstract

Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group × training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exerciseinduced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.

Original language	English
Journal	Journal of Applied Physiology
Volume	112
Issue number	6
Pages (from-to)	990-1000
Number of pages	11
ISSN	8750-7587
DOIs	https://doi.org/10.1152/japplphysiol.01027.2010
Publication status	Published - Mar 2012

Keywords

Adult
Antioxidants
Ascorbic Acid
Body Mass Index
Catalase
Dietary Supplements
Double-Blind Method
Exercise
Glutathione Peroxidase
Humans
Hydrocortisone
Interleukin 1 Receptor Antagonist Protein
Interleukin-6
Male
Muscle Proteins
Muscle, Skeletal
Oxidative Stress
Physical Endurance
Superoxide Dismutase
Vitamin E

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10.1152/japplphysiol.01027.2010

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@article{1a3cef1ac5a54de8b6c7afb62d3ebc9f,

title = "Role of vitamin C and E supplementation on IL-6 in response to training",

abstract = "Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group × training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exerciseinduced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.",

keywords = "Adult, Antioxidants, Ascorbic Acid, Body Mass Index, Catalase, Dietary Supplements, Double-Blind Method, Exercise, Glutathione Peroxidase, Humans, Hydrocortisone, Interleukin 1 Receptor Antagonist Protein, Interleukin-6, Male, Muscle Proteins, Muscle, Skeletal, Oxidative Stress, Physical Endurance, Superoxide Dismutase, Vitamin E, vitamin C, vitamin E, endurance exercise, interleukin-6",

author = "Christina Yfanti and Fischer, {Christian P.} and S{\o}ren Nielsen and Thorbj{\"o}rn {\AA}kerstr{\"o}m and Nielsen, {Anders R.} and Veskoukis, {Aristidis S.} and Demetrios Kouretas and Jens Lykkesfeldt and Henriette Pilegaard and Pedersen, {Bente Klarlund}",

year = "2012",

month = mar,

doi = "10.1152/japplphysiol.01027.2010",

language = "English",

volume = "112",

pages = "990--1000",

journal = "Journal of Applied Physiology",

issn = "8750-7587",

publisher = "American Physiological Society",

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TY - JOUR

T1 - Role of vitamin C and E supplementation on IL-6 in response to training

AU - Yfanti, Christina

AU - Fischer, Christian P.

AU - Nielsen, Søren

AU - Åkerström, Thorbjörn

AU - Nielsen, Anders R.

AU - Veskoukis, Aristidis S.

AU - Kouretas, Demetrios

AU - Lykkesfeldt, Jens

AU - Pilegaard, Henriette

AU - Pedersen, Bente Klarlund

PY - 2012/3

Y1 - 2012/3

N2 - Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group × training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exerciseinduced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.

AB - Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group × training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exerciseinduced increases in plasma IL-6 there is no clear additive effect when combined with endurance training.

KW - Adult

KW - Antioxidants

KW - Ascorbic Acid

KW - Body Mass Index

KW - Catalase

KW - Dietary Supplements

KW - Double-Blind Method

KW - Exercise

KW - Glutathione Peroxidase

KW - Humans

KW - Hydrocortisone

KW - Interleukin 1 Receptor Antagonist Protein

KW - Interleukin-6

KW - Male

KW - Muscle Proteins

KW - Muscle, Skeletal

KW - Oxidative Stress

KW - Physical Endurance

KW - Superoxide Dismutase

KW - Vitamin E

KW - vitamin C

KW - vitamin E

KW - endurance exercise

KW - interleukin-6

U2 - 10.1152/japplphysiol.01027.2010

DO - 10.1152/japplphysiol.01027.2010

M3 - Journal article

C2 - 22207723

SN - 8750-7587

VL - 112

SP - 990

EP - 1000

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

IS - 6

ER -

Role of vitamin C and E supplementation on IL-6 in response to training

Abstract

Keywords

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