Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

Anne Louise Sørensen; Viktoria Rumjantseva; Sara Nayeb-Hashemi; Henrik Clausen; John H Hartwig; Hans H Wandall; Karin M Hoffmeister

doi:10.1182/blood-2009-01-199414

Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

Anne Louise Sørensen, Viktoria Rumjantseva, Sara Nayeb-Hashemi, Henrik Clausen, John H Hartwig, Hans H Wandall, Karin M Hoffmeister

130 Citations (Scopus)

Abstract

Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIbalpha as a major counterreceptor on ST3Gal-IV(-/-) platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function.

Original language	English
Journal	Blood
Volume	114
Issue number	8
Pages (from-to)	1645-54
Number of pages	9
ISSN	0006-4971
DOIs	https://doi.org/10.1182/blood-2009-01-199414
Publication status	Published - 2009

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Sørensen, A. L., Rumjantseva, V., Nayeb-Hashemi, S., Clausen, H., Hartwig, J. H., Wandall, H. H., & Hoffmeister, K. M. (2009). Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood, 114(8), 1645-54. https://doi.org/10.1182/blood-2009-01-199414

Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. / Sørensen, Anne Louise; Rumjantseva, Viktoria; Nayeb-Hashemi, Sara et al.

In: Blood, Vol. 114, No. 8, 2009, p. 1645-54.

Research output: Contribution to journal › Journal article › Research › peer-review

Sørensen, AL, Rumjantseva, V, Nayeb-Hashemi, S, Clausen, H, Hartwig, JH, Wandall, HH & Hoffmeister, KM 2009, 'Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes', Blood, vol. 114, no. 8, pp. 1645-54. https://doi.org/10.1182/blood-2009-01-199414

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abstract = "Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIbalpha as a major counterreceptor on ST3Gal-IV(-/-) platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function.",

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AU - Nayeb-Hashemi, Sara

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AU - Hartwig, John H

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