Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

Anne Louise Sørensen; Viktoria Rumjantseva; Sara Nayeb-Hashemi; Henrik Clausen; John H Hartwig; Hans H Wandall; Karin M Hoffmeister

doi:10.1182/blood-2009-01-199414

Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

Anne Louise Sørensen, Viktoria Rumjantseva, Sara Nayeb-Hashemi, Henrik Clausen, John H Hartwig, Hans H Wandall, Karin M Hoffmeister

130 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Aug-20

Originalsprog	Engelsk
Tidsskrift	Blood
Vol/bind	114
Udgave nummer	8
Sider (fra-til)	1645-54
Antal sider	9
ISSN	0006-4971
DOI	https://doi.org/10.1182/blood-2009-01-199414
Status	Udgivet - 2009

Adgang til dokumentet

10.1182/blood-2009-01-199414

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Citationsformater

Sørensen, A. L., Rumjantseva, V., Nayeb-Hashemi, S., Clausen, H., Hartwig, J. H., Wandall, H. H., & Hoffmeister, K. M. (2009). Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. Blood, 114(8), 1645-54. https://doi.org/10.1182/blood-2009-01-199414

Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes. / Sørensen, Anne Louise; Rumjantseva, Viktoria; Nayeb-Hashemi, Sara et al.

I: Blood, Bind 114, Nr. 8, 2009, s. 1645-54.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Sørensen, AL, Rumjantseva, V, Nayeb-Hashemi, S, Clausen, H, Hartwig, JH, Wandall, HH & Hoffmeister, KM 2009, 'Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes', Blood, bind 114, nr. 8, s. 1645-54. https://doi.org/10.1182/blood-2009-01-199414

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title = "Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes",

abstract = "Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIbalpha as a major counterreceptor on ST3Gal-IV(-/-) platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function.",

author = "S{\o}rensen, {Anne Louise} and Viktoria Rumjantseva and Sara Nayeb-Hashemi and Henrik Clausen and Hartwig, {John H} and Wandall, {Hans H} and Hoffmeister, {Karin M}",

year = "2009",

doi = "10.1182/blood-2009-01-199414",

language = "English",

volume = "114",

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T1 - Role of sialic acid for platelet life span: exposure of beta-galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes

AU - Sørensen, Anne Louise

AU - Rumjantseva, Viktoria

AU - Nayeb-Hashemi, Sara

AU - Clausen, Henrik

AU - Hartwig, John H

AU - Wandall, Hans H

AU - Hoffmeister, Karin M

PY - 2009

Y1 - 2009

N2 - Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIbalpha as a major counterreceptor on ST3Gal-IV(-/-) platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function.

AB - Although surface sialic acid is considered a key determinant for the survival of circulating blood cells and glycoproteins, its role in platelet circulation lifetime is not fully clarified. We show that thrombocytopenia in mice deficient in the St3gal4 sialyltransferase gene (St3Gal-IV(-/-) mice) is caused by the recognition of terminal galactose residues exposed on the platelet surface in the absence of sialylation. This results in accelerated platelet clearance by asialoglycoprotein receptor-expressing scavenger cells, a mechanism that was recently shown to induce thrombocytopenia during Streptococcus pneumoniae sepsis. We now identify platelet GPIbalpha as a major counterreceptor on ST3Gal-IV(-/-) platelets for asialoglycoprotein receptors. Moreover, we report data that establish the importance of sialylation of the von Willebrand factor in its function.

U2 - 10.1182/blood-2009-01-199414

DO - 10.1182/blood-2009-01-199414

M3 - Journal article

C2 - 19520807

SN - 0006-4971

VL - 114

SP - 1645

EP - 1654

JO - Blood

JF - Blood

IS - 8

ER -