Role of protein dynamics in transmembrane receptor signalling

Yong Wang; Katrine Østergaard Bugge; Birthe Brandt Kragelund; Kresten Lindorff-Larsen

doi:10.1016/j.sbi.2017.10.017

Role of protein dynamics in transmembrane receptor signalling

Yong Wang, Katrine Østergaard Bugge, Birthe Brandt Kragelund, Kresten Lindorff-Larsen

Biomolecular Sciences

12 Citationer (Scopus)

Abstract

Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Structural Biology
Vol/bind	48
Sider (fra-til)	74-82
Antal sider	9
ISSN	0959-440X
DOI	https://doi.org/10.1016/j.sbi.2017.10.017
Status	Udgivet - feb. 2018

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10.1016/j.sbi.2017.10.017

Citationsformater

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title = "Role of protein dynamics in transmembrane receptor signalling",

abstract = "Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.",

keywords = "Journal Article, Review",

author = "Yong Wang and Bugge, {Katrine {\O}stergaard} and Kragelund, {Birthe Brandt} and Kresten Lindorff-Larsen",

year = "2018",

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doi = "10.1016/j.sbi.2017.10.017",

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T1 - Role of protein dynamics in transmembrane receptor signalling

AU - Wang, Yong

AU - Bugge, Katrine Østergaard

AU - Kragelund, Birthe Brandt

AU - Lindorff-Larsen, Kresten

PY - 2018/2

Y1 - 2018/2

N2 - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

AB - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.

KW - Journal Article

KW - Review

U2 - 10.1016/j.sbi.2017.10.017

DO - 10.1016/j.sbi.2017.10.017

M3 - Review

C2 - 29136528

SN - 0959-440X

VL - 48

SP - 74

EP - 82

JO - Current Opinion in Structural Biology

JF - Current Opinion in Structural Biology

ER -

Role of protein dynamics in transmembrane receptor signalling

Abstract

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