Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection

Andreas N Madsen; Anneline Nansen; Jan P Christensen; Allan R Thomsen

Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection

Andreas N Madsen, Anneline Nansen, Jan P Christensen, Allan R Thomsen

Department of Immunology and Microbiology

9 Citations (Scopus)

Abstract

The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity.

Original language	English
Journal	Journal of Virology
Volume	77
Issue number	22
Pages (from-to)	12378-84
Number of pages	6
ISSN	0022-538X
Publication status	Published - 2003

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title = "Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection",

abstract = "The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity.",

author = "Madsen, {Andreas N} and Anneline Nansen and Christensen, {Jan P} and Thomsen, {Allan R}",

note = "Keywords: Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Cell Movement; Chemokine CCL3; Chemokine CCL4; Hypersensitivity, Delayed; Lymphocytic Choriomeningitis; Macrophage Inflammatory Proteins; Mice; T-Lymphocytes",

year = "2003",

language = "English",

volume = "77",

pages = "12378--84",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "22",

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TY - JOUR

T1 - Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection

AU - Madsen, Andreas N

AU - Nansen, Anneline

AU - Christensen, Jan P

AU - Thomsen, Allan R

N1 - Keywords: Animals; Antigens, Viral; CD8-Positive T-Lymphocytes; Cell Movement; Chemokine CCL3; Chemokine CCL4; Hypersensitivity, Delayed; Lymphocytic Choriomeningitis; Macrophage Inflammatory Proteins; Mice; T-Lymphocytes

PY - 2003

Y1 - 2003

N2 - The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity.

AB - The immune response to lymphocytic choriomeningitis virus in mice lacking macrophage inflammatory protein-1alpha (MIP-1alpha) was evaluated. Generation of virus-specific effector T cells is unimpaired in MIP-1alpha-deficient mice. Furthermore, MIP-1alpha is not required for T-cell-mediated virus control or virus-induced T-cell-dependent inflammation. Thus, MIP-1alpha is not mandatory for T-cell-mediated antiviral immunity.

M3 - Journal article

C2 - 14581577

SN - 0022-538X

VL - 77

SP - 12378

EP - 12384

JO - Journal of Virology

JF - Journal of Virology

IS - 22

ER -

Role of macrophage inflammatory protein-1alpha in T-cell-mediated immunity to viral infection

Abstract

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