Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Dominique de Ziegler; Paul Pirtea; Claus Yding Andersen; Jean Marc Ayoubi

doi:10.1016/j.fertnstert.2018.03.006

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Dominique de Ziegler^*, Paul Pirtea, Claus Yding Andersen, Jean Marc Ayoubi

^*Corresponding author for this work

Department of Clinical Medicine

9 Citations (Scopus)

Abstract

Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

Original language	English
Journal	Fertility and Sterility
Volume	109
Issue number	5
Pages (from-to)	749-755
Number of pages	7
ISSN	0015-0282
DOIs	https://doi.org/10.1016/j.fertnstert.2018.03.006
Publication status	Published - 2018

Keywords

ART
GnRH agonist
luteal phase support
ovarian stimulation
Progesterone

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de Ziegler, D., Pirtea, P., Andersen, C. Y., & Ayoubi, J. M. (2018). Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped. Fertility and Sterility, 109(5), 749-755. https://doi.org/10.1016/j.fertnstert.2018.03.006

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped. / de Ziegler, Dominique; Pirtea, Paul; Andersen, Claus Yding et al.
In: Fertility and Sterility, Vol. 109, No. 5, 2018, p. 749-755.

Research output: Contribution to journal › Review › peer-review

de Ziegler, D, Pirtea, P, Andersen, CY & Ayoubi, JM 2018, 'Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped', Fertility and Sterility, vol. 109, no. 5, pp. 749-755. https://doi.org/10.1016/j.fertnstert.2018.03.006

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abstract = "Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.",

keywords = "ART, GnRH agonist, luteal phase support, ovarian stimulation, Progesterone",

author = "{de Ziegler}, Dominique and Paul Pirtea and Andersen, {Claus Yding} and Ayoubi, {Jean Marc}",

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AU - de Ziegler, Dominique

AU - Pirtea, Paul

AU - Andersen, Claus Yding

AU - Ayoubi, Jean Marc

PY - 2018

Y1 - 2018

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KW - ART

KW - GnRH agonist

KW - luteal phase support

KW - ovarian stimulation

KW - Progesterone

U2 - 10.1016/j.fertnstert.2018.03.006

DO - 10.1016/j.fertnstert.2018.03.006

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