Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Dominique de Ziegler; Paul Pirtea; Claus Yding Andersen; Jean Marc Ayoubi

doi:10.1016/j.fertnstert.2018.03.006

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

Dominique de Ziegler^*, Paul Pirtea, Claus Yding Andersen, Jean Marc Ayoubi

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin

9 Citationer (Scopus)

Abstract

Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

Originalsprog	Engelsk
Tidsskrift	Fertility and Sterility
Vol/bind	109
Udgave nummer	5
Sider (fra-til)	749-755
Antal sider	7
ISSN	0015-0282
DOI	https://doi.org/10.1016/j.fertnstert.2018.03.006
Status	Udgivet - 2018

Adgang til dokumentet

10.1016/j.fertnstert.2018.03.006

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Citationsformater

de Ziegler, D., Pirtea, P., Andersen, C. Y., & Ayoubi, J. M. (2018). Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped. Fertility and Sterility, 109(5), 749-755. https://doi.org/10.1016/j.fertnstert.2018.03.006

Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped. / de Ziegler, Dominique; Pirtea, Paul; Andersen, Claus Yding et al.
I: Fertility and Sterility, Bind 109, Nr. 5, 2018, s. 749-755.

Publikation: Bidrag til tidsskrift › Review › peer review

de Ziegler, D, Pirtea, P, Andersen, CY & Ayoubi, JM 2018, 'Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped', Fertility and Sterility, bind 109, nr. 5, s. 749-755. https://doi.org/10.1016/j.fertnstert.2018.03.006

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title = "Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped",

abstract = "Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.",

keywords = "ART, GnRH agonist, luteal phase support, ovarian stimulation, Progesterone",

author = "{de Ziegler}, Dominique and Paul Pirtea and Andersen, {Claus Yding} and Ayoubi, {Jean Marc}",

year = "2018",

doi = "10.1016/j.fertnstert.2018.03.006",

language = "English",

volume = "109",

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T1 - Role of gonadotropin-releasing hormone agonists, human chorionic gonadotropin (hCG), progesterone, and estrogen in luteal phase support after hCG triggering, and when in pregnancy hormonal support can be stopped

AU - de Ziegler, Dominique

AU - Pirtea, Paul

AU - Andersen, Claus Yding

AU - Ayoubi, Jean Marc

PY - 2018

Y1 - 2018

N2 - Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

AB - Luteal phase support is mandatory in ovarian stimulation cycles in assisted reproductive technology owing to a deficit in LH pulsatility after the effects of exogenous hCG—used for triggering ovulation—vanish. This is classically accomplished by means of exogenous P administration, but emerging new options include microdoses of hCG and exogenous GnRH agonist. Although luteal phase support is commonly continued for up to 10 weeks into pregnancy, there is accumulating evidence that it can be stopped after the first ultrasound or even after a positive pregnancy test.

KW - ART

KW - GnRH agonist

KW - luteal phase support

KW - ovarian stimulation

KW - Progesterone

U2 - 10.1016/j.fertnstert.2018.03.006

DO - 10.1016/j.fertnstert.2018.03.006

M3 - Review

C2 - 29778367

AN - SCOPUS:85047147672

SN - 0015-0282

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JO - Fertility and Sterility

JF - Fertility and Sterility

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ER -