Robust Microbubble Tracking for Super Resolution Imaging in Ultrasound

kristoffer B Hansen; Carlos A Villagómez-Hoyos; Jens Christian Brasen; Konstantinos Diamantis; Vassilis Sboros; Charlotte Mehlin Sørensen; Jørgen Arendt Jensen

doi:10.1109/ULTSYM.2016.7728793

Robust Microbubble Tracking for Super Resolution Imaging in Ultrasound

kristoffer B Hansen, Carlos A Villagómez-Hoyos, Jens Christian Brasen, Konstantinos Diamantis, Vassilis Sboros, Charlotte Mehlin Sørensen, Jørgen Arendt Jensen

Renal and Vascular Research

13 Citations (Scopus)

Abstract

Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.

Original language	English
Title of host publication	2016 IEEE International Ultrasonics Symposium
Number of pages	4
Publisher	IEEE
Publication date	1 Nov 2016
DOIs	https://doi.org/10.1109/ULTSYM.2016.7728793
Publication status	Published - 1 Nov 2016
Event	2016 IEEE International Ultrasonics Symposium - Duration: 18 Sept 2016 → 21 Sept 2016

Conference

Conference	2016 IEEE International Ultrasonics Symposium
Period	18/09/2016 → 21/09/2016

Series	IEEE International Ultrasonics Symposium Proceedings

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10.1109/ULTSYM.2016.7728793

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Robust Microbubble Tracking for Super Resolution Imaging in Ultrasound. / Hansen, kristoffer B; Villagómez-Hoyos, Carlos A; Brasen, Jens Christian et al.
2016 IEEE International Ultrasonics Symposium. IEEE, 2016. (IEEE International Ultrasonics Symposium Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Hansen, KB, Villagómez-Hoyos, CA, Brasen, JC, Diamantis, K, Sboros, V, Sørensen, CM & Jensen, JA 2016, Robust Microbubble Tracking for Super Resolution Imaging in Ultrasound. in 2016 IEEE International Ultrasonics Symposium. IEEE, IEEE International Ultrasonics Symposium Proceedings, 2016 IEEE International Ultrasonics Symposium , 18/09/2016. https://doi.org/10.1109/ULTSYM.2016.7728793

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abstract = "Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.",

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doi = "10.1109/ULTSYM.2016.7728793",

language = "English",

series = "IEEE International Ultrasonics Symposium Proceedings",

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AU - Hansen, kristoffer B

AU - Villagómez-Hoyos, Carlos A

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AU - Sboros, Vassilis

AU - Sørensen, Charlotte Mehlin

AU - Jensen, Jørgen Arendt

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N2 - Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.

AB - Currently ultrasound resolution is limited by diffraction to approximately half the wavelength of the sound wave employed. In recent years, super resolution imaging techniques have overcome the diffraction limit through the localization and tracking of a sparse set of microbubbles through the vasculature. However, this has only been performed on fixated tissue, limiting its clinical application. This paper proposes a technique for making super resolution images on non-fixated tissue by first compensating for tissue movement and then tracking the individual microbubbles. The experiment is performed on the kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue at 0.1× original concentration. The algorithm demonstrated in vivo that the motion compensation was capable of removing the movement caused by the mechanical ventilator. The results shows that microbubbles were localized with a higher precision, reducing the standard deviation of the super localizations from 22μm to 8 μm. The paper proves that the restriction of completely fixated tissue can be eliminated, when making super resolution imaging with microbubbles.

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M3 - Article in proceedings

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PB - IEEE

T2 - 2016 IEEE International Ultrasonics Symposium

Y2 - 18 September 2016 through 21 September 2016

ER -

Robust Microbubble Tracking for Super Resolution Imaging in Ultrasound

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