Abstract
Currently ultrasound resolution is limited by diffraction
to approximately half the wavelength of the sound wave
employed. In recent years, super resolution imaging techniques
have overcome the diffraction limit through the localization and
tracking of a sparse set of microbubbles through the vasculature.
However, this has only been performed on fixated tissue, limiting
its clinical application. This paper proposes a technique
for making super resolution images on non-fixated tissue by
first compensating for tissue movement and then tracking the
individual microbubbles. The experiment is performed on the
kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue
at 0.1 original concentration. The algorithm demonstrated in
vivo that the motion compensation was capable of removing
the movement caused by the mechanical ventilator. The results
shows that microbubbles were localized with a higher precision,
reducing the standard deviation of the super localizations from
22μm to 8 μm. The paper proves that the restriction of completely
fixated tissue can be eliminated, when making super resolution
imaging with microbubbles.
to approximately half the wavelength of the sound wave
employed. In recent years, super resolution imaging techniques
have overcome the diffraction limit through the localization and
tracking of a sparse set of microbubbles through the vasculature.
However, this has only been performed on fixated tissue, limiting
its clinical application. This paper proposes a technique
for making super resolution images on non-fixated tissue by
first compensating for tissue movement and then tracking the
individual microbubbles. The experiment is performed on the
kidney of a anesthetized Sprage-Dawley rat by infusing SonoVue
at 0.1 original concentration. The algorithm demonstrated in
vivo that the motion compensation was capable of removing
the movement caused by the mechanical ventilator. The results
shows that microbubbles were localized with a higher precision,
reducing the standard deviation of the super localizations from
22μm to 8 μm. The paper proves that the restriction of completely
fixated tissue can be eliminated, when making super resolution
imaging with microbubbles.
| Originalsprog | Engelsk |
|---|---|
| Titel | 2016 IEEE International Ultrasonics Symposium |
| Antal sider | 4 |
| Forlag | IEEE |
| Publikationsdato | 1 nov. 2016 |
| DOI | |
| Status | Udgivet - 1 nov. 2016 |
| Begivenhed | 2016 IEEE International Ultrasonics Symposium - Varighed: 18 sep. 2016 → 21 sep. 2016 |
Konference
| Konference | 2016 IEEE International Ultrasonics Symposium |
|---|---|
| Periode | 18/09/2016 → 21/09/2016 |
| Navn | IEEE International Ultrasonics Symposium Proceedings |
|---|