Risiko for anastomoselækage ved postoperativ behandling med nonsteroide antiinflammatoriske stoffer: Risk of anastomotic leakage in postoperative treatment with non-steroidal anti-inflammatory drugs

M. Klein; Ismayil Gögenür; J. Rosenberg

Risiko for anastomoselækage ved postoperativ behandling med nonsteroide antiinflammatoriske stoffer: Risk of anastomotic leakage in postoperative treatment with non-steroidal anti-inflammatory drugs

3 Citations (Scopus)

Abstract

Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis

Original language	Danish
Journal	Ugeskrift for Laeger
Volume	172
Issue number	22
Pages (from-to)	1660-1662
Number of pages	3
ISSN	0041-5782
Publication status	Published - 2010

Cite this

Risiko for anastomoselækage ved postoperativ behandling med nonsteroide antiinflammatoriske stoffer : Risk of anastomotic leakage in postoperative treatment with non-steroidal anti-inflammatory drugs. / Klein, M.; Gögenür, Ismayil ; Rosenberg, J.

In: Ugeskrift for Laeger, Vol. 172, No. 22, 2010, p. 1660-1662.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis",

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AU - Klein, M.

AU - Gögenür, Ismayil

AU - Rosenberg, J.

PY - 2010

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N2 - Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis

AB - Anastomotic leakage is the most serious complication following colorectal resection. Recently, focus has been on possible effects of non-steroidal anti-inflammatory drugs (NSAIDs). Animal studies have found a correlation between treatment with NSAIDs and increased leakage rate, impaired anastomotic strength and reduced deposition of hydroxyproline. Retrospective human studies have reported increased leakage rates after postoperative diclofenac and celecoxib treatment. We recommend that diclofenac and celecoxib be omitted from analgesic regimens after colorectal surgery involving an anastomosis

M3 - Tidsskriftartikel

SN - 0041-5782

VL - 172

SP - 1660

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JO - Ugeskrift for Laeger

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