Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

Jakob B Sørensen

doi:10.1083/jcb.201706007

Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

Jakob B Sørensen

Neuronal Signalling

3 Citations (Scopus)

43 Downloads (Pure)

Abstract

The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

Original language	English
Journal	Journal of Cell Biology
Volume	216
Issue number	7
Pages (from-to)	1887-1889
Number of pages	3
ISSN	0021-9525
DOIs	https://doi.org/10.1083/jcb.201706007
Publication status	Published - 1 Jul 2017

Keywords

Animals
Exocytosis
Protein Transport
SNARE Proteins
Secretory Vesicles
trans-Golgi Network
Journal Article

Access to Document

10.1083/jcb.201706007Licence: CC BY-NC-SA

Ride the wave: Retrograde trafficking becomes Ca2+ dependent with BAIAP3Final published version, 535 KBLicence: CC BY-NC-SA

Cite this

@article{59fb723f0d5a46c980dce51af34d6bd6,

title = "Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3",

abstract = "The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.",

keywords = "Animals, Exocytosis, Protein Transport, SNARE Proteins, Secretory Vesicles, trans-Golgi Network, Journal Article",

author = "S{\o}rensen, {Jakob B}",

note = "{\textcopyright} 2017 S{\o}rensen.",

year = "2017",

month = jul,

day = "1",

doi = "10.1083/jcb.201706007",

language = "English",

volume = "216",

pages = "1887--1889",

journal = "Journal of Cell Biology",

issn = "0021-9525",

publisher = "Rockefeller University Press",

number = "7",

}

TY - JOUR

T1 - Ride the wave

T2 - Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

AU - Sørensen, Jakob B

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

AB - The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

KW - Animals

KW - Exocytosis

KW - Protein Transport

KW - SNARE Proteins

KW - Secretory Vesicles

KW - trans-Golgi Network

KW - Journal Article

U2 - 10.1083/jcb.201706007

DO - 10.1083/jcb.201706007

M3 - Comment/debate

C2 - 28626002

SN - 0021-9525

VL - 216

SP - 1887

EP - 1889

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 7

ER -

Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

Abstract

Keywords

Access to Document

Fingerprint

Cite this