Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

Jakob B Sørensen

doi:10.1083/jcb.201706007

Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

Jakob B Sørensen

Neuronal Signalling

3 Citationer (Scopus)

43 Downloads (Pure)

Abstract

The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

Originalsprog	Engelsk
Tidsskrift	Journal of Cell Biology
Vol/bind	216
Udgave nummer	7
Sider (fra-til)	1887-1889
Antal sider	3
ISSN	0021-9525
DOI	https://doi.org/10.1083/jcb.201706007
Status	Udgivet - 1 jul. 2017

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10.1083/jcb.201706007Licens: CC BY-NC-SA

Ride the wave: Retrograde trafficking becomes Ca2+ dependent with BAIAP3Forlagets udgivne version, 535 KBLicens: CC BY-NC-SA

Citationsformater

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abstract = "The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.",

keywords = "Animals, Exocytosis, Protein Transport, SNARE Proteins, Secretory Vesicles, trans-Golgi Network, Journal Article",

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year = "2017",

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AU - Sørensen, Jakob B

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N2 - The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

AB - The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.

KW - Animals

KW - Exocytosis

KW - Protein Transport

KW - SNARE Proteins

KW - Secretory Vesicles

KW - trans-Golgi Network

KW - Journal Article

U2 - 10.1083/jcb.201706007

DO - 10.1083/jcb.201706007

M3 - Comment/debate

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SN - 0021-9525

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SP - 1887

EP - 1889

JO - Journal of Cell Biology

JF - Journal of Cell Biology

IS - 7

ER -

Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3

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