Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

D Fuglø; K Kallenbach; A Tsakiri; A E Hansen; E Rostrup; H B W Larsson; Helle Juhl Simonsen; Birgit Agnes Sander; Jette Lautrup Battistini Frederiksen

doi:10.1212/wnl.0b013e3182299e36

Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

D Fuglø, K Kallenbach, A Tsakiri, A E Hansen, E Rostrup, H B W Larsson, Helle Juhl Simonsen, Birgit Agnes Sander, Jette Lautrup Battistini Frederiksen

Department of Clinical Medicine

5 Citations (Scopus)

Abstract

Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period. Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery. Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.

Original language	English
Journal	Neurology
Volume	77
Issue number	7
Pages (from-to)	645-51
Number of pages	7
ISSN	0028-3878
DOIs	https://doi.org/10.1212/wnl.0b013e3182299e36
Publication status	Published - 16 Aug 2011

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title = "Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis",

abstract = "Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period. Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery. Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.",

author = "D Fugl{\o} and K Kallenbach and A Tsakiri and Hansen, {A E} and E Rostrup and Larsson, {H B W} and Simonsen, {Helle Juhl} and Sander, {Birgit Agnes} and Frederiksen, {Jette Lautrup Battistini}",

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doi = "10.1212/wnl.0b013e3182299e36",

language = "English",

volume = "77",

pages = "645--51",

journal = "Neurology",

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TY - JOUR

T1 - Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

AU - Fuglø, D

AU - Kallenbach, K

AU - Tsakiri, A

AU - Hansen, A E

AU - Rostrup, E

AU - Larsson, H B W

AU - Simonsen, Helle Juhl

AU - Sander, Birgit Agnes

AU - Frederiksen, Jette Lautrup Battistini

PY - 2011/8/16

Y1 - 2011/8/16

N2 - Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period. Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery. Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.

AB - Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period. Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery. Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.

U2 - 10.1212/wnl.0b013e3182299e36

DO - 10.1212/wnl.0b013e3182299e36

M3 - Journal article

SN - 0028-3878

VL - 77

SP - 645

EP - 651

JO - Neurology

JF - Neurology

IS - 7

ER -

Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

Abstract

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