Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

TY - JOUR

T1 - Retinal atrophy correlates with fMRI response in patients with recovered optic neuritis

AU - Fuglø, D

AU - Kallenbach, K

AU - Tsakiri, A

AU - Hansen, A E

AU - Rostrup, E

AU - Larsson, H B W

AU - Simonsen, Helle Juhl

AU - Sander, Birgit Agnes

AU - Frederiksen, Jette Lautrup Battistini

PY - 2011/8/16

Y1 - 2011/8/16

N2 - Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period. Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery. Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.

AB - Objective: We wanted to investigate if retinal nerve fiber layer thickness (RNFLT) measured by optical coherence tomography (OCT) might be a good marker of acute and chronic changes in the afferent visual pathway following acute optic neuritis (ON). Methods: We studied the relationship of optic nerve lesion length, optic nerve mean area, and RNFLT, quantified by OCT, with fMRI response to a visual paradigm in 40 patients with acute ON and 19 healthy controls in a prospective cohort study over a 6-month period. Results: The main finding was a significant correlation of optic nerve lesion length and mean area with fMRI response in affected eyes in the acute phase and between RNFLT and fMRI response in affected eyes after recovery. Conclusion: RNFLT is a very good measure of damage to the afferent visual pathway in recovered patients with ON and should be included in future fMRI studies when looking for visual reorganization in recovered patients with ON.

U2 - 10.1212/wnl.0b013e3182299e36

DO - 10.1212/wnl.0b013e3182299e36

M3 - Journal article

SN - 0028-3878

VL - 77

SP - 645

EP - 651

JO - Neurology

JF - Neurology

IS - 7

ER -