Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern

Gerda Thomsen; Robin de Nijs; Esben Hogh-Rasmussen; Vibe Frokjaer; Claus Svarer; Gitte M Knudsen

doi:10.1007/s00259-008-0836-8

Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern

Gerda Thomsen, Robin de Nijs, Esben Hogh-Rasmussen, Vibe Frokjaer, Claus Svarer, Gitte M Knudsen

Department of Clinical Medicine

8 Citations (Scopus)

Abstract

Functional brain (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) is a useful diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease and epilepsy. Currently, the European and American Association of Nuclear Medicine Procedure Guidelines for Brain Perfusion SPET using (99m)Tc-labeled Radiopharmaceuticals recommend a time delay of 90 min between injection of (99m)Tc-HMPAO and data acquisition. This time delay is difficult to comply within the daily routine and present a problem, particularly with the elderly or demented patients. This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min.

Original language	English
Journal	European Journal of Nuclear Medicine and Molecular Imaging
Volume	35
Issue number	12
Pages (from-to)	2212-9
Number of pages	8
ISSN	1619-7070
DOIs	https://doi.org/10.1007/s00259-008-0836-8
Publication status	Published - 1 Dec 2008

Keywords

Adult
Aged
Aged, 80 and over
Case-Control Studies
Cerebrovascular Circulation
Female
Health
Humans
Injections
Male
Middle Aged
Principal Component Analysis
Radioactivity
Subtraction Technique
Technetium Tc 99m Exametazime
Time Factors
Tomography, Emission-Computed, Single-Photon

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10.1007/s00259-008-0836-8

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Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern. / Thomsen, Gerda; de Nijs, Robin; Hogh-Rasmussen, Esben et al.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 35, No. 12, 01.12.2008, p. 2212-9.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Functional brain (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) is a useful diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease and epilepsy. Currently, the European and American Association of Nuclear Medicine Procedure Guidelines for Brain Perfusion SPET using (99m)Tc-labeled Radiopharmaceuticals recommend a time delay of 90 min between injection of (99m)Tc-HMPAO and data acquisition. This time delay is difficult to comply within the daily routine and present a problem, particularly with the elderly or demented patients. This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min.",

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AU - Thomsen, Gerda

AU - de Nijs, Robin

AU - Hogh-Rasmussen, Esben

AU - Frokjaer, Vibe

AU - Svarer, Claus

AU - Knudsen, Gitte M

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AB - Functional brain (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) is a useful diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease and epilepsy. Currently, the European and American Association of Nuclear Medicine Procedure Guidelines for Brain Perfusion SPET using (99m)Tc-labeled Radiopharmaceuticals recommend a time delay of 90 min between injection of (99m)Tc-HMPAO and data acquisition. This time delay is difficult to comply within the daily routine and present a problem, particularly with the elderly or demented patients. This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min.

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KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Cerebrovascular Circulation

KW - Female

KW - Health

KW - Humans

KW - Injections

KW - Male

KW - Middle Aged

KW - Principal Component Analysis

KW - Radioactivity

KW - Subtraction Technique

KW - Technetium Tc 99m Exametazime

KW - Time Factors

KW - Tomography, Emission-Computed, Single-Photon

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DO - 10.1007/s00259-008-0836-8

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SN - 1619-7070

VL - 35

SP - 2212

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JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 12

ER -

Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern

Abstract

Keywords

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