Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern

TY - JOUR

T1 - Required time delay from 99mTc-HMPAO injection to SPECT data acquisition: healthy subjects and patients with rCBF pattern

AU - Thomsen, Gerda

AU - de Nijs, Robin

AU - Hogh-Rasmussen, Esben

AU - Frokjaer, Vibe

AU - Svarer, Claus

AU - Knudsen, Gitte M

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Functional brain (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) is a useful diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease and epilepsy. Currently, the European and American Association of Nuclear Medicine Procedure Guidelines for Brain Perfusion SPET using (99m)Tc-labeled Radiopharmaceuticals recommend a time delay of 90 min between injection of (99m)Tc-HMPAO and data acquisition. This time delay is difficult to comply within the daily routine and present a problem, particularly with the elderly or demented patients. This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min.

AB - Functional brain (99m)Tc-HMPAO single-photon emission computed tomography (SPECT) is a useful diagnostic tool for assessment of regional cerebral blood flow, particularly in dementia, cerebrovascular disease and epilepsy. Currently, the European and American Association of Nuclear Medicine Procedure Guidelines for Brain Perfusion SPET using (99m)Tc-labeled Radiopharmaceuticals recommend a time delay of 90 min between injection of (99m)Tc-HMPAO and data acquisition. This time delay is difficult to comply within the daily routine and present a problem, particularly with the elderly or demented patients. This study investigates in patients with perfusion deficits and in healthy subjects if the quality of the SPECT image is affected by lowering the time delay between (99m)Tc-HMPAO injection and data acquisition to 30 or 60 min.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Case-Control Studies

KW - Cerebrovascular Circulation

KW - Female

KW - Health

KW - Humans

KW - Injections

KW - Male

KW - Middle Aged

KW - Principal Component Analysis

KW - Radioactivity

KW - Subtraction Technique

KW - Technetium Tc 99m Exametazime

KW - Time Factors

KW - Tomography, Emission-Computed, Single-Photon

U2 - 10.1007/s00259-008-0836-8

DO - 10.1007/s00259-008-0836-8

M3 - Journal article

C2 - 18542960

SN - 1619-7070

VL - 35

SP - 2212

EP - 2219

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

IS - 12

ER -