Replication: DNA Building Block Synthesis On Demand

C Holmberg; O Nielsen

doi:10.1016/j.cub.2012.03.019

Replication: DNA Building Block Synthesis On Demand

C Holmberg, O Nielsen

Functional Genomics

2 Citations (Scopus)

Abstract

Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

Original language	English
Journal	Current Biology
Volume	22
Issue number	8
Pages (from-to)	R271-R272
Number of pages	2
ISSN	0960-9822
DOIs	https://doi.org/10.1016/j.cub.2012.03.019
Publication status	Published - 24 Apr 2012

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10.1016/j.cub.2012.03.019

http://www.sciencedirect.com/science/article/pii/S0960982212003065

Cite this

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title = "Replication: DNA Building Block Synthesis On Demand",

abstract = "Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.",

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AU - Nielsen, O

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AB - Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

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DO - 10.1016/j.cub.2012.03.019

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VL - 22

SP - R271-R272

JO - Current Biology

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Replication: DNA Building Block Synthesis On Demand

Abstract

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