Replication: DNA Building Block Synthesis On Demand

C Holmberg; O Nielsen

doi:10.1016/j.cub.2012.03.019

Replication: DNA Building Block Synthesis On Demand

C Holmberg, O Nielsen

Functional genomics

2 Citationer (Scopus)

Abstract

Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

Originalsprog	Engelsk
Tidsskrift	Current Biology
Vol/bind	22
Udgave nummer	8
Sider (fra-til)	R271-R272
Antal sider	2
ISSN	0960-9822
DOI	https://doi.org/10.1016/j.cub.2012.03.019
Status	Udgivet - 24 apr. 2012

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10.1016/j.cub.2012.03.019

http://www.sciencedirect.com/science/article/pii/S0960982212003065

Citationsformater

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AB - Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.

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Replication: DNA Building Block Synthesis On Demand

Abstract

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