Abstract
To investigate the hormonal and cellular selectivity of the prandial glucose regulators, we have undertaken a series of experiments, in which we characterised the effects of repaglinide and nateglinide on ATP-sensitive potassium ion (KATP) channel activity, membrane potential and exocytosis in rat pancreatic alpha-cells and somatotrophs. We found a pharmacological dissociation between the actions on KATP channels and exocytosis and suggest that compounds that, unlike repaglinide, have direct stimulatory effects on exocytosis in somatotrophs and alpha- and beta-cells, such as sulphonylureas and nateglinide, may have a clinically undesirable general stimulatory effect on cells within the endocrine system.
| Original language | English |
|---|---|
| Journal | Diabetes, nutrition & metabolism |
| Volume | 15 |
| Issue number | 6 Suppl |
| Pages (from-to) | 15-8 |
| Number of pages | 4 |
| ISSN | 0394-3402 |
| Publication status | Published - Dec 2002 |
Keywords
- Animals
- Carbamates
- Cyclohexanes
- Electrophysiology
- Exocytosis
- Hypoglycemic Agents
- Islets of Langerhans
- Membrane Potentials
- Phenylalanine
- Piperidines
- Postprandial Period
- Potassium Channels
- Rats