Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation

Lasse S Ravn; Jacob Hofman-Bang; Ulrik Dixen; Severin Olesen Larsen; Gorm Jensen; Stig Haunsø; Jesper Hastrup Svendsen; Michael Christiansen

doi:10.1016/j.amjcard.2005.03.086

Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation

Lasse S Ravn, Jacob Hofman-Bang, Ulrik Dixen, Severin Olesen Larsen, Gorm Jensen, Stig Haunsø, Jesper Hastrup Svendsen, Michael Christiansen

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Abstract

The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.

Original language	English
Journal	American Journal of Cardiology
Volume	96
Issue number	3
Pages (from-to)	405-7
Number of pages	2
ISSN	0002-9149
DOIs	https://doi.org/10.1016/j.amjcard.2005.03.086
Publication status	Published - 2005

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@article{3a5e0820a30111df928f000ea68e967b,

title = "Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation",

abstract = "The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.",

author = "Ravn, {Lasse S} and Jacob Hofman-Bang and Ulrik Dixen and Larsen, {Severin Olesen} and Gorm Jensen and Stig Hauns{\o} and Svendsen, {Jesper Hastrup} and Michael Christiansen",

note = "Keywords: Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Chi-Square Distribution; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Potassium Channels, Voltage-Gated; Risk Assessment",

year = "2005",

doi = "10.1016/j.amjcard.2005.03.086",

language = "English",

volume = "96",

pages = "405--7",

journal = "American Journal of Cardiology",

issn = "0002-9149",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation

AU - Ravn, Lasse S

AU - Hofman-Bang, Jacob

AU - Dixen, Ulrik

AU - Larsen, Severin Olesen

AU - Jensen, Gorm

AU - Haunsø, Stig

AU - Svendsen, Jesper Hastrup

AU - Christiansen, Michael

N1 - Keywords: Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Chi-Square Distribution; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Potassium Channels, Voltage-Gated; Risk Assessment

PY - 2005

Y1 - 2005

N2 - The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.

AB - The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.

U2 - 10.1016/j.amjcard.2005.03.086

DO - 10.1016/j.amjcard.2005.03.086

M3 - Journal article

C2 - 16054468

SN - 0002-9149

VL - 96

SP - 405

EP - 407

JO - American Journal of Cardiology

JF - American Journal of Cardiology

IS - 3

ER -

Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation

Abstract

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