TY - JOUR
T1 - Relation of 97T polymorphism in KCNE5 to risk of atrial fibrillation
AU - Ravn, Lasse S
AU - Hofman-Bang, Jacob
AU - Dixen, Ulrik
AU - Larsen, Severin Olesen
AU - Jensen, Gorm
AU - Haunsø, Stig
AU - Svendsen, Jesper Hastrup
AU - Christiansen, Michael
N1 - Keywords: Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Case-Control Studies; Chi-Square Distribution; Female; Genotype; Humans; Male; Middle Aged; Polymorphism, Genetic; Potassium Channels, Voltage-Gated; Risk Assessment
PY - 2005
Y1 - 2005
N2 - The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.
AB - The 97T polymorphism of the KCNE5 gene, coding for an inhibitory beta-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.
U2 - 10.1016/j.amjcard.2005.03.086
DO - 10.1016/j.amjcard.2005.03.086
M3 - Journal article
C2 - 16054468
SN - 0002-9149
VL - 96
SP - 405
EP - 407
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
IS - 3
ER -