Abstract
Interleukin-1beta (IL-1beta) is a pivotal mediator in the inflammatory immune response that is characteristic of a number of chronic disorders. The etiology and pathophysiology of inflammatory bowel disease (IBD) have for many years been an enigma. The recent identification of the inflammasome, a multiprotein complex responsible for interleukin-1beta converting enzyme (ICE, caspase-1) activation, has generated new possibilities for the elucidation of the etiology and pathophysiology of IBD and as a consequence also for the identification of new treatment targets.
| Translated title of the contribution | Regulation of cytokine production in inflammatory bowel disease |
|---|---|
| Original language | Danish |
| Journal | Ugeskrift for Laeger |
| Volume | 168 |
| Issue number | 19 |
| Pages (from-to) | 1847-50 |
| Number of pages | 4 |
| ISSN | 0041-5782 |
| Publication status | Published - 2006 |