TY - JOUR
T1 - Regulation of T cell migration during viral infection: role of adhesion molecules and chemokines
AU - Thomsen, Allan Randrup
AU - Nansen, Anneline
AU - Madsen, Andreas Nygaard
AU - Bartholdy, Christina
AU - Christensen, Jan Pravsgaard
N1 - Keywords: Animals; CD8-Positive T-Lymphocytes; Cell Adhesion Molecules; Cell Movement; Chemokines; Humans; Integrins; Receptors, Chemokine; Selectins; T-Lymphocyte Subsets; Virus Diseases; Viruses
PY - 2003
Y1 - 2003
N2 - T cell mediated immunity and in particular CD8+ T cells are pivotal for the control of most viral infections. T cells exclusively exert their antiviral effect through close cellular interaction with relevant virus-infected target cells in vivo. It is therefore imperative that efficient mechanisms exist, which will rapidly direct newly generated effector T cells to sites of viral replication. In the present report we have reviewed our present knowledge concerning the molecular interactions, which are important in targeting of effector CD8+ T cells to sites of viral infection.
AB - T cell mediated immunity and in particular CD8+ T cells are pivotal for the control of most viral infections. T cells exclusively exert their antiviral effect through close cellular interaction with relevant virus-infected target cells in vivo. It is therefore imperative that efficient mechanisms exist, which will rapidly direct newly generated effector T cells to sites of viral replication. In the present report we have reviewed our present knowledge concerning the molecular interactions, which are important in targeting of effector CD8+ T cells to sites of viral infection.
M3 - Journal article
C2 - 12527217
SN - 0165-2478
VL - 85
SP - 119
EP - 127
JO - Immunology Letters
JF - Immunology Letters
IS - 2
ER -