Regulation of mitotic progression by the spindle assembly checkpoint

Tiziana Lischetti; Jakob Nilsson

doi:10.4161/23723548.2014.970484

Regulation of mitotic progression by the spindle assembly checkpoint

30 Citations (Scopus)

Abstract

Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to establish proper attachments. Anaphase entry is inhibited by the checkpoint through assembly of the mitotic checkpoint complex (MCC) composed of the 2 checkpoint proteins, Mad2 and BubR1, bound to Cdc20. The outer kinetochore acts as a catalyst for MCC production through the recruitment and proper positioning of checkpoint proteins and recently there has been remarkable progress in understanding how this is achieved. Here, we highlight recent advances in our understanding of kinetochore-checkpoint protein interactions and inhibition of the anaphase promoting complex by the MCC.

Original language	English
Journal	Molecular & Cellular Oncology
Volume	2
Issue number	1
Pages (from-to)	e970484
ISSN	2372-3556
DOIs	https://doi.org/10.4161/23723548.2014.970484
Publication status	Published - 2 Jan 2015

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AU - Nilsson, Jakob

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AB - Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to establish proper attachments. Anaphase entry is inhibited by the checkpoint through assembly of the mitotic checkpoint complex (MCC) composed of the 2 checkpoint proteins, Mad2 and BubR1, bound to Cdc20. The outer kinetochore acts as a catalyst for MCC production through the recruitment and proper positioning of checkpoint proteins and recently there has been remarkable progress in understanding how this is achieved. Here, we highlight recent advances in our understanding of kinetochore-checkpoint protein interactions and inhibition of the anaphase promoting complex by the MCC.

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Regulation of mitotic progression by the spindle assembly checkpoint

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