Regulation of mitotic progression by the spindle assembly checkpoint

Tiziana Lischetti; Jakob Nilsson

doi:10.4161/23723548.2014.970484

Regulation of mitotic progression by the spindle assembly checkpoint

30 Citationer (Scopus)

Abstract

Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to establish proper attachments. Anaphase entry is inhibited by the checkpoint through assembly of the mitotic checkpoint complex (MCC) composed of the 2 checkpoint proteins, Mad2 and BubR1, bound to Cdc20. The outer kinetochore acts as a catalyst for MCC production through the recruitment and proper positioning of checkpoint proteins and recently there has been remarkable progress in understanding how this is achieved. Here, we highlight recent advances in our understanding of kinetochore-checkpoint protein interactions and inhibition of the anaphase promoting complex by the MCC.

Originalsprog	Engelsk
Tidsskrift	Molecular & Cellular Oncology
Vol/bind	2
Udgave nummer	1
Sider (fra-til)	e970484
ISSN	2372-3556
DOI	https://doi.org/10.4161/23723548.2014.970484
Status	Udgivet - 2 jan. 2015

Adgang til dokumentet

10.4161/23723548.2014.970484

23723548.2014.970484?needAccess=trueForlagets udgivne version, 2,27 MB

Citationsformater

@article{1e58475407ab4392923e0b6ce0eb7a78,

title = "Regulation of mitotic progression by the spindle assembly checkpoint",

abstract = "Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to establish proper attachments. Anaphase entry is inhibited by the checkpoint through assembly of the mitotic checkpoint complex (MCC) composed of the 2 checkpoint proteins, Mad2 and BubR1, bound to Cdc20. The outer kinetochore acts as a catalyst for MCC production through the recruitment and proper positioning of checkpoint proteins and recently there has been remarkable progress in understanding how this is achieved. Here, we highlight recent advances in our understanding of kinetochore-checkpoint protein interactions and inhibition of the anaphase promoting complex by the MCC.",

keywords = "Journal Article, Review",

author = "Tiziana Lischetti and Jakob Nilsson",

year = "2015",

month = jan,

day = "2",

doi = "10.4161/23723548.2014.970484",

language = "English",

volume = "2",

pages = "e970484",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor & Francis",

number = "1",

}

TY - JOUR

T1 - Regulation of mitotic progression by the spindle assembly checkpoint

AU - Lischetti, Tiziana

AU - Nilsson, Jakob

PY - 2015/1/2

Y1 - 2015/1/2

N2 - Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to establish proper attachments. Anaphase entry is inhibited by the checkpoint through assembly of the mitotic checkpoint complex (MCC) composed of the 2 checkpoint proteins, Mad2 and BubR1, bound to Cdc20. The outer kinetochore acts as a catalyst for MCC production through the recruitment and proper positioning of checkpoint proteins and recently there has been remarkable progress in understanding how this is achieved. Here, we highlight recent advances in our understanding of kinetochore-checkpoint protein interactions and inhibition of the anaphase promoting complex by the MCC.

AB - Equal segregation of sister chromatids during mitosis requires that pairs of kinetochores establish proper attachment to microtubules emanating from opposite poles of the mitotic spindle. The spindle assembly checkpoint (SAC) protects against errors in segregation by delaying sister separation in response to improper kinetochore-microtubule interactions, and certain checkpoint proteins help to establish proper attachments. Anaphase entry is inhibited by the checkpoint through assembly of the mitotic checkpoint complex (MCC) composed of the 2 checkpoint proteins, Mad2 and BubR1, bound to Cdc20. The outer kinetochore acts as a catalyst for MCC production through the recruitment and proper positioning of checkpoint proteins and recently there has been remarkable progress in understanding how this is achieved. Here, we highlight recent advances in our understanding of kinetochore-checkpoint protein interactions and inhibition of the anaphase promoting complex by the MCC.

KW - Journal Article

KW - Review

U2 - 10.4161/23723548.2014.970484

DO - 10.4161/23723548.2014.970484

M3 - Journal article

C2 - 27308407

SN - 2372-3556

VL - 2

SP - e970484

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 1

ER -

Regulation of mitotic progression by the spindle assembly checkpoint

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater