Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report

Carsten Dirksen; Siv H Jacobsen; Kirstine N Bojsen-Møller; Nils B Jørgensen; Lars S Naver; Lisbeth E Hvolris; Dorte Worm; Sten Madsbad; Jens Juul Holst; Dorte L Hansen

doi:10.1016/j.orcp.2012.01.002

Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report

Carsten Dirksen, Siv H Jacobsen, Kirstine N Bojsen-Møller, Nils B Jørgensen, Lars S Naver, Lisbeth E Hvolris, Dorte Worm, Sten Madsbad, Jens Juul Holst, Dorte L Hansen

12 Citations (Scopus)

Abstract

Experience with Roux-en-Y gastric bypass in patients with type 1 diabetes is very limited, despite an increasing prevalence of obesity also in this population. We describe changes in anthropometric measures, insulin dose, HbA1c, blood pressure, lipid status, and metabolic response to a liquid mixed meal throughout the first year after RYGB in an obese patient with type 1 diabetes. No change in HbA1c was observed, but a 48% reduction in weight-adjusted insulin dose and improvements in cardiovascular risk factors was seen 1 year after surgery. Exaggerated secretions of anorexigenic gut hormones were seen during the meals.

Original language	English
Journal	Obesity Research & Clinical Practice
Volume	7
Issue number	4
Pages (from-to)	e269-74
Number of pages	6
ISSN	1871-403X
DOIs	https://doi.org/10.1016/j.orcp.2012.01.002
Publication status	Published - Jul 2013

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Dirksen, C., Jacobsen, S. H., Bojsen-Møller, K. N., Jørgensen, N. B., Naver, L. S., Hvolris, L. E., Worm, D., Madsbad, S., Holst, J. J., & Hansen, D. L. (2013). Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report. Obesity Research & Clinical Practice, 7(4), e269-74. https://doi.org/10.1016/j.orcp.2012.01.002

Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report. / Dirksen, Carsten; Jacobsen, Siv H; Bojsen-Møller, Kirstine N et al.
In: Obesity Research & Clinical Practice, Vol. 7, No. 4, 07.2013, p. e269-74.

Research output: Contribution to journal › Journal article › Research › peer-review

Dirksen, C, Jacobsen, SH, Bojsen-Møller, KN, Jørgensen, NB, Naver, LS, Hvolris, LE, Worm, D , Madsbad, S , Holst, JJ & Hansen, DL 2013, 'Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report', Obesity Research & Clinical Practice, vol. 7, no. 4, pp. e269-74. https://doi.org/10.1016/j.orcp.2012.01.002

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abstract = "Experience with Roux-en-Y gastric bypass in patients with type 1 diabetes is very limited, despite an increasing prevalence of obesity also in this population. We describe changes in anthropometric measures, insulin dose, HbA1c, blood pressure, lipid status, and metabolic response to a liquid mixed meal throughout the first year after RYGB in an obese patient with type 1 diabetes. No change in HbA1c was observed, but a 48% reduction in weight-adjusted insulin dose and improvements in cardiovascular risk factors was seen 1 year after surgery. Exaggerated secretions of anorexigenic gut hormones were seen during the meals.",

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AU - Bojsen-Møller, Kirstine N

AU - Jørgensen, Nils B

AU - Naver, Lars S

AU - Hvolris, Lisbeth E

AU - Worm, Dorte

AU - Madsbad, Sten

AU - Holst, Jens Juul

AU - Hansen, Dorte L

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AB - Experience with Roux-en-Y gastric bypass in patients with type 1 diabetes is very limited, despite an increasing prevalence of obesity also in this population. We describe changes in anthropometric measures, insulin dose, HbA1c, blood pressure, lipid status, and metabolic response to a liquid mixed meal throughout the first year after RYGB in an obese patient with type 1 diabetes. No change in HbA1c was observed, but a 48% reduction in weight-adjusted insulin dose and improvements in cardiovascular risk factors was seen 1 year after surgery. Exaggerated secretions of anorexigenic gut hormones were seen during the meals.

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DO - 10.1016/j.orcp.2012.01.002

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Reduction in cardiovascular risk factors and insulin dose, but no beta-cell regeneration 1 year after Roux-en-Y gastric bypass in an obese patient with type 1 diabetes: a case report

Abstract

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