TY - JOUR
T1 - Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters
AU - Andersen, Jacob
AU - Kristensen, Anders Skov
AU - Bang-Andersen, Benny
AU - Strømgaard, Kristian
N1 - Keywords: Animals; Antidepressive Agents; Humans; Models, Molecular; Norepinephrine Plasma Membrane Transport Proteins; Serotonin Plasma Membrane Transport Proteins; Serotonin Uptake Inhibitors; Structure-Activity Relationship
PY - 2009
Y1 - 2009
N2 - The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.
AB - The biogenic monoamine transporters are integral membrane proteins that perform active transport of extracellular dopamine, serotonin and norepinephrine into cells. These transporters are targets for therapeutic agents such as antidepressants, as well as addictive substances such as cocaine and amphetamine. Seminal advances in the understanding of the structure and function of this transporter family have recently been accomplished by structural studies of a bacterial transporter, as well as medicinal chemistry and pharmacological studies of mammalian transporters. This feature article focuses on antidepressant drugs that act on the serotonin and/or the norepinephrine transporters. Specifically, we focus on structure-activity relationships of these drugs with emphasis on relationships between their molecular properties and the current knowledge of transporter structure.
KW - Former Faculty of Pharmaceutical Sciences
U2 - 10.1039/b903035m
DO - 10.1039/b903035m
M3 - Journal article
C2 - 19557250
SN - 1359-7345
SP - 3677
EP - 3692
JO - Chemical Communications
JF - Chemical Communications
IS - 25
ER -