Recent advances in cryo-TEM imaging of soft lipid nanoparticles

Shen Yu Helvig; Intan Diana Binti Mat Azmi; Seyed Moien Moghimi; Anan Yaghmur

doi:10.3934/biophy.2015.2.116

Recent advances in cryo-TEM imaging of soft lipid nanoparticles

Shen Yu Helvig, Intan Diana Binti Mat Azmi, Seyed Moien Moghimi, Anan Yaghmur

28 Citations (Scopus)

Abstract

Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.

Original language	English
Journal	AIMS Biophysics
Volume	2
Issue number	2
Pages (from-to)	116-130
Number of pages	15
DOIs	https://doi.org/10.3934/biophy.2015.2.116
Publication status	Published - 2015

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10.3934/biophy.2015.2.116

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AB - Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.

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Recent advances in cryo-TEM imaging of soft lipid nanoparticles

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