Recent advances in cryo-TEM imaging of soft lipid nanoparticles

TY - JOUR

T1 - Recent advances in cryo-TEM imaging of soft lipid nanoparticles

AU - Helvig, Shen Yu

AU - Mat Azmi, Intan Diana Binti

AU - Moghimi, Seyed Moien

AU - Yaghmur, Anan

PY - 2015

Y1 - 2015

N2 - Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.

AB - Cryo-transmission electron microscopy (Cryo-TEM), and its technological variations thereof, have become a powerful tool for detailed morphological characterization and 3D tomography of soft lipid and polymeric nanoparticles as well as biological materials such as viruses and DNA without chemical fixation. Here, we review and discuss recent advances in Cryo-TEM analysis of lipid-based drug nanocarriers with particular emphasis on morphological and internal nanostructure characterization of lyotropic liquid crystalline nanoparticles such as cubosomes and hexosomes.

U2 - 10.3934/biophy.2015.2.116

DO - 10.3934/biophy.2015.2.116

M3 - Journal article

SN - 2377-9098

VL - 2

SP - 116

EP - 130

JO - AIMS Biophysics

JF - AIMS Biophysics

IS - 2

ER -