Real-time UV imaging of nicotin release from transdermal patch

Jesper Østergaard; Emil Meng-Lund; Susan Weng Larsen; Claus Selch Larsen; Karsten Petersson; James Lenke; Henrik Jensen

doi:10.1007/s11095-010-0257-9

Real-time UV imaging of nicotin release from transdermal patch

Jesper Østergaard, Emil Meng-Lund, Susan Weng Larsen, Claus Selch Larsen, Karsten Petersson, James Lenke, Henrik Jensen

69 Citationer (Scopus)

Abstract

PURPOSE:
This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system.
METHODS:
The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.
RESULTS:
Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.
CONCLUSION:
Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.

Originalsprog	Engelsk
Tidsskrift	Pharmaceutical Research
Vol/bind	27
Sider (fra-til)	2614-2623
ISSN	0724-8741
DOI	https://doi.org/10.1007/s11095-010-0257-9
Status	Udgivet - dec. 2010

Emneord

Det tidligere Farmaceutiske Fakultet

Adgang til dokumentet

10.1007/s11095-010-0257-9

Citationsformater

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title = "Real-time UV imaging of nicotin release from transdermal patch",

abstract = "PURPOSE:This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette{\textregistered} nicotine patches as a model drug delivery system.METHODS:The rate of nicotine release from 2 mm diameter patch samples (Nicorette{\textregistered}) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.RESULTS:Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.CONCLUSION:Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.",

keywords = "Former Faculty of Pharmaceutical Sciences",

author = "Jesper {\O}stergaard and Emil Meng-Lund and Larsen, {Susan Weng} and Larsen, {Claus Selch} and Karsten Petersson and James Lenke and Henrik Jensen",

year = "2010",

month = dec,

doi = "10.1007/s11095-010-0257-9",

language = "English",

volume = "27",

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T1 - Real-time UV imaging of nicotin release from transdermal patch

AU - Østergaard, Jesper

AU - Meng-Lund, Emil

AU - Larsen, Susan Weng

AU - Larsen, Claus Selch

AU - Petersson, Karsten

AU - Lenke, James

AU - Jensen, Henrik

PY - 2010/12

Y1 - 2010/12

N2 - PURPOSE:This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system.METHODS:The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.RESULTS:Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.CONCLUSION:Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.

AB - PURPOSE:This study was conducted to characterize UV imaging as a platform for performing in vitro release studies using Nicorette® nicotine patches as a model drug delivery system.METHODS:The rate of nicotine release from 2 mm diameter patch samples (Nicorette®) into 0.067 M phosphate buffer, pH 7.40, was studied by UV imaging (Actipix SDI300 dissolution imaging system) at 254 nm. The release rates were compared to those obtained using the paddle-over-disk method.RESULTS:Calibration curves were successfully established which allowed temporally and spatially resolved quantification of nicotine. Release profiles obtained from UV imaging were in qualitative agreement with results from the paddle-over-disk release method.CONCLUSION:Visualization as well as quantification of nicotine concentration gradients was achieved by UV imaging in real time. UV imaging has the potential to become an important technology platform for conducting in vitro drug release studies.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1007/s11095-010-0257-9

DO - 10.1007/s11095-010-0257-9

M3 - Journal article

C2 - 20811931

SN - 0724-8741

VL - 27

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EP - 2623

JO - Pharmaceutical Research

JF - Pharmaceutical Research

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