Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

Katja Spiess; Mads G. Jeppesen; Mikkel Malmgaard-Clausen; Karen Krzywkowski; Kalpana Dulal; Tong Cheng; Gertrud M. Hjorto; Olav Larsen; John S. Burg; Michael A. Jarvis; K. Christopher Garcia; Hua Zhu; Thomas N. Kledal; Mette M. Rosenkilde

doi:10.1073/pnas.1509392112

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

Katja Spiess, Mads G. Jeppesen, Mikkel Malmgaard-Clausen, Karen Krzywkowski, Kalpana Dulal, Tong Cheng, Gertrud M. Hjorto, Olav Larsen, John S. Burg, Michael A. Jarvis, K. Christopher Garcia, Hua Zhu, Thomas N. Kledal, Mette M. Rosenkilde

Institut for Neurovidenskab

25 Citationer (Scopus)

Originalsprog	Engelsk
Tidsskrift	Proceedings of the National Academy of Sciences of the United States of America
Vol/bind	112
Udgave nummer	27
Sider (fra-til)	8427-8432
Antal sider	6
ISSN	0027-8424
DOI	https://doi.org/10.1073/pnas.1509392112
Status	Udgivet - 7 jul. 2015

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10.1073/pnas.1509392112

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Spiess, K., Jeppesen, M. G., Malmgaard-Clausen, M., Krzywkowski, K., Dulal, K., Cheng, T., Hjorto, G. M., Larsen, O., Burg, J. S., Jarvis, M. A., Garcia, K. C., Zhu, H., Kledal, T. N., & Rosenkilde, M. M. (2015). Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proceedings of the National Academy of Sciences of the United States of America, 112(27), 8427-8432. https://doi.org/10.1073/pnas.1509392112

Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. / Spiess, Katja; Jeppesen, Mads G.; Malmgaard-Clausen, Mikkel et al.

I: Proceedings of the National Academy of Sciences of the United States of America, Bind 112, Nr. 27, 07.07.2015, s. 8427-8432.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Spiess, K, Jeppesen, MG, Malmgaard-Clausen, M, Krzywkowski, K, Dulal, K, Cheng, T, Hjorto, GM , Larsen, O, Burg, JS, Jarvis, MA, Garcia, KC, Zhu, H, Kledal, TN & Rosenkilde, MM 2015, 'Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo', Proceedings of the National Academy of Sciences of the United States of America, bind 112, nr. 27, s. 8427-8432. https://doi.org/10.1073/pnas.1509392112

Spiess K, Jeppesen MG, Malmgaard-Clausen M, Krzywkowski K, Dulal K, Cheng T et al. Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2015 jul. 7;112(27):8427-8432. doi: 10.1073/pnas.1509392112

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title = "Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo",

keywords = "HCMV, 7TM GPCR, protein engineering, antiviral drug, chemokine",

author = "Katja Spiess and Jeppesen, {Mads G.} and Mikkel Malmgaard-Clausen and Karen Krzywkowski and Kalpana Dulal and Tong Cheng and Hjorto, {Gertrud M.} and Olav Larsen and Burg, {John S.} and Jarvis, {Michael A.} and Garcia, {K. Christopher} and Hua Zhu and Kledal, {Thomas N.} and Rosenkilde, {Mette M.}",

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AU - Spiess, Katja

AU - Jeppesen, Mads G.

AU - Malmgaard-Clausen, Mikkel

AU - Krzywkowski, Karen

AU - Dulal, Kalpana

AU - Cheng, Tong

AU - Hjorto, Gertrud M.

AU - Larsen, Olav

AU - Burg, John S.

AU - Jarvis, Michael A.

AU - Garcia, K. Christopher

AU - Zhu, Hua

AU - Kledal, Thomas N.

AU - Rosenkilde, Mette M.

PY - 2015/7/7

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KW - 7TM GPCR

KW - protein engineering

KW - antiviral drug

KW - chemokine

U2 - 10.1073/pnas.1509392112

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M3 - Journal article

C2 - 26080445

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 27

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Rationally designed chemokine-based toxin targeting the viral G protein-coupled receptor US28 potently inhibits cytomegalovirus infection in vivo

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